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Current Sexual Health Reports

, Volume 11, Issue 3, pp 132–143 | Cite as

Plant-Derived Supplements for Sexual Health and Problems: Part 1—Trends over the Past Decade

  • David L. RowlandEmail author
  • Sean M. McNabney
  • Allyse M. Donarski
Preclinical and Psychophysiology (F Guarraci and L Marson, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Preclinical and Psychophysiology

Abstract

Purpose of Review

In this update on plant-derived supplements, we provide a general introduction regarding the status and interest in phytochemicals for sexual health, indicating both progress and problems with past and current research.

Recent Findings

We summarize the development and current status of two well-known plant-derived supplements, using them as case studies for understanding some of the problems associated with the study of such supplements on sexual health.

Summary

We interpret the current situation regarding plant-derived supplements, identify common sources/journals for information about medicinal herbs for sexual health, identify supplements that are garnering increasing attention within the research community, and discuss the larger potential and pitfalls associated with this domain of research.

Keywords

Phytochemicals Herbs Plant-derived supplements Sexual health Sexual dysfunction Sexual desire Erectile function 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. 1.
    Laumann EO, Gagnon JH, Michael RT, Michaels S. The social organization of sexuality: sexual practices in the United States. Chicago, IL: The University of Chicago Press; 1994.Google Scholar
  2. 2.
    •• Wallace TC. Twenty years of the dietary supplement health and education act--how should dietary supplements be regulated? J Nutr. 2015;145(8):1683–6.  https://doi.org/10.3945/jn.115.211102. A good primer and discussion regarding the status of supplements and their regulation. CrossRefPubMedGoogle Scholar
  3. 3.
    Bailey RL. Current regulatory guidelines and resources to support research of dietary supplements in the United States. Critical reviews in food science and nutrition. 2018:1–12.  https://doi.org/10.1080/10408398.2018.1524364.
  4. 4.
    Cui T, Kovell RC, Brooks DC, Terlecki RP. A Urologist’s guide to ingredients found in top-selling nutraceuticals for men’s sexual health. J Sex Med. 2015;12(11):2105–17.  https://doi.org/10.1111/jsm.13013.CrossRefPubMedGoogle Scholar
  5. 5.
    • Rowland DL, Burek M, Macias L. Plant-derivatives and herbs used for the promotion of sexual health and the treatment of sexual problems. Annual Review of Sex Research. 2007;18(1):225–57.  https://doi.org/10.1080/10532528.2007.10559852. Although dated, this review provides a comprehensive perspective of the state of plant-derived supplements slightly over a decade ago, providing a good perspective for the “then” and “now” analysis. CrossRefGoogle Scholar
  6. 6.
    Rowland D, Tai W. A review of plant-derived and herbal approaches to the treatment of sexual dysfunctions. J Sex Marital Ther. 2003;29(3):185–205.  https://doi.org/10.1080/00926230390155096.CrossRefPubMedGoogle Scholar
  7. 7.
    Aung HH, Dey L, Rand V, Yuan CS. Alternative therapies for male and female sexual dysfunction. Am J Chin Med. 2004;32(2):161–73.  https://doi.org/10.1142/s0192415x04001837.CrossRefPubMedGoogle Scholar
  8. 8.
    McKay D. Nutrients and botanicals for erectile dysfunction: examining the evidence. Altern Med Rev. 2004;9(1):4–16.PubMedGoogle Scholar
  9. 9.
    Rowland DL, Kallan K, Slob AK. Yohimbine, erectile capacity, and sexual response in men. Arch Sex Behav. 1997;26(1):49–62.CrossRefPubMedGoogle Scholar
  10. 10.
    Moyad MA, Barada JH, Lue TF, Mulhall JP, Goldstein I, Fawzy A. Prevention and treatment of erectile dysfunction using lifestyle changes and dietary supplements: what works and what is worthless, part II. Urol Clin N Am. 2004;31(2):259–73.  https://doi.org/10.1016/j.ucl.2004.01.007.CrossRefGoogle Scholar
  11. 11.
    •• Hao YF, Jiang JG. Origin and evolution of China pharmacopoeia and its implication for traditional medicines. Mini Rev Med Chem. 2015;15(7):595–603. An interesting description and discussion of the modern China pharmacopoeia, which often makes reference to traditional and natural drugs, with such compounds often challenged in terms of authenticity and by lack of understanding of mechanisms of action and adverse reactions. CrossRefPubMedGoogle Scholar
  12. 12.
    Li FS, Weng JK. Demystifying traditional herbal medicine with modern approach. Nat Plants. 2017;3:17109.  https://doi.org/10.1038/nplants.2017.109.CrossRefPubMedGoogle Scholar
  13. 13.
    Ho CC, Tan HM. Rise of herbal and traditional medicine in erectile dysfunction management. Curr Urol Rep. 2011;12(6):470–8.  https://doi.org/10.1007/s11934-011-0217-x.CrossRefPubMedGoogle Scholar
  14. 14.
    •• West E, Krychman M. Natural aphrodisiacs-a review of selected sexual enhancers. Sexual medicine reviews. 2015;3(4):279–88.  https://doi.org/10.1002/smrj.62. A substantive review of animal and plant-derived supplements for sexual response in both men and women, covering a range of compounds, including commercial products. Provides a good orientation to some of the issues and products in this field. CrossRefPubMedGoogle Scholar
  15. 15.
    Kim EH, Larson JA, Andriole GL. Management of benign prostatic hyperplasia. Annu Rev Med. 2016;67:137–51.  https://doi.org/10.1146/annurev-med-063014-123902.CrossRefPubMedGoogle Scholar
  16. 16.
    Bennett BC, Hicklin JR. Uses of saw palmetto (Serenoa repens, Arecaceae) in Florida. Economic Botany. 1998;52(4):381–93.  https://doi.org/10.1007/BF02862068.CrossRefGoogle Scholar
  17. 17.
    Jaiswal Y, Weber D, Yerke A, Xue Y, Lehman D, Williams T, et al. A substitute variety for agronomically and medicinally important Serenoa repens (saw palmetto). Scientific reports. 2019;9(1):4709.  https://doi.org/10.1038/s41598-019-41150-z.CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    Penugonda K, Lindshield BL. Fatty acid and phytosterol content of commercial saw palmetto supplements. Nutrients. 2013;5(9):3617–33.  https://doi.org/10.3390/nu5093617.CrossRefPubMedPubMedCentralGoogle Scholar
  19. 19.
    Ghusn HF, Shao TC, Klima M, Cunningham GR. 4-MAPC, a 5 alpha-reductase inhibitor, reduces rat ventral prostate weight, DNA, and prostatein concentrations. J Androl. 1991;12(5):315–22.PubMedGoogle Scholar
  20. 20.
    Niu Y, Xu Y, Zhang J, Bai J, Yang H, Ma T. Proliferation and differentiation of prostatic stromal cells. BJU international. 2001;87(4):386–93.CrossRefPubMedGoogle Scholar
  21. 21.
    Herati AS, Kohn TP, Butler PR, Lipshultz LI. Effects of testosterone on benign and malignant conditions of the prostate. Curr Sex Health Rep. 2017;9(2):65–73.  https://doi.org/10.1007/s11930-017-0104-7.CrossRefPubMedPubMedCentralGoogle Scholar
  22. 22.
    Rastrelli G, Vignozzi L, Corona G, Maggi M. Testosterone and benign prostatic hyperplasia. Sexual medicine reviews. 2019;7(2):259–71.  https://doi.org/10.1016/j.sxmr.2018.10.006.CrossRefPubMedGoogle Scholar
  23. 23.
    Rowland D, Motofei I, Păunică I, Banu P, Nistor M, Păunică S, et al. Androgenic alopecia; the risk–benefit ratio of Finasteride. J Mind Med Sci. 2018;5(1):1–6.  https://doi.org/10.22543/7674.51.P16.CrossRefGoogle Scholar
  24. 24.
    Zlotta AR, Teillac P, Raynaud JP, Schulman CC. Evaluation of male sexual function in patients with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) treated with a phytotherapeutic agent (Permixon), tamsulosin or finasteride. Eur Urol. 2005;48(2):269–76.  https://doi.org/10.1016/j.eururo.2005.03.029.CrossRefPubMedGoogle Scholar
  25. 25.
    Yang S, Chen C, Li Y, Ren Z, Zhang Y, Wu G, et al. Saw palmetto extract enhances erectile responses by inhibition of phosphodiesterase 5 activity and increase in inducible nitric oxide synthase messenger ribonucleic acid expression in rat and rabbit corpus cavernosum. Urology. 2013;81(6):1380.e7-13.  https://doi.org/10.1016/j.urology.2012.12.062.CrossRefPubMedGoogle Scholar
  26. 26.
    Espinosa-Juarez JV, Colado-Velazquez JI, Mailloux-Salinas P, Medina-Contreras J, Correa-Lopez PV, Gomez-Viquez NL, et al. Beneficial effects of lipidic extracts of saladette tomato pomace and Serenoa repens on prostate and bladder health in obese male Wistar rats. J Sci Food Agric. 2017;97(13):4451–8.  https://doi.org/10.1002/jsfa.8308.CrossRefPubMedGoogle Scholar
  27. 27.
    Bent S, Kane C, Shinohara K, Neuhaus J, Hudes ES, Goldberg H, et al. Saw palmetto for benign prostatic hyperplasia. The New England journal of medicine. 2006;354(6):557–66.  https://doi.org/10.1056/NEJMoa053085.CrossRefPubMedGoogle Scholar
  28. 28.
    Barry MJ, Meleth S, Lee JY, Kreder KJ, Avins AL, Nickel JC, et al. Effect of increasing doses of saw palmetto extract on lower urinary tract symptoms: a randomized trial. Jama. 2011;306(12):1344–51.  https://doi.org/10.1001/jama.2011.1364.CrossRefPubMedPubMedCentralGoogle Scholar
  29. 29.
    Avins AL, Lee JY, Meyers CM, Barry MJ. Safety and toxicity of saw palmetto in the CAMUS trial. J Urol. 2013;189(4):1415–20.  https://doi.org/10.1016/j.juro.2012.10.002.CrossRefPubMedGoogle Scholar
  30. 30.
    Tacklind J, Macdonald R, Rutks I, Stanke JU, Wilt TJ. Serenoa repens for benign prostatic hyperplasia. Cochrane Database Syst Rev. 2012;12:Cd001423.  https://doi.org/10.1002/14651858.CD001423.pub3.CrossRefPubMedGoogle Scholar
  31. 31.
    Morgia G, Russo GI, Voce S, Palmieri F, Gentile M, Giannantoni A, et al. Serenoa repens, lycopene and selenium versus tamsulosin for the treatment of LUTS/BPH. An Italian multicenter double-blinded randomized study between single or combination therapy (PROCOMB trial). The Prostate. 2014;74(15):1471–80.  https://doi.org/10.1002/pros.22866.CrossRefPubMedGoogle Scholar
  32. 32.
    • Agbabiaka TB, Pittler MH, Wider B, Ernst E. Serenoa repens (saw palmetto): a systematic review of adverse events. Drug Saf. 2009;32(8):637–47.  https://doi.org/10.2165/00002018-200932080-00003 A review dashing the initial hopes that saw palmetto could serve as a natural promoter of prostate health. CrossRefPubMedGoogle Scholar
  33. 33.
    Asher GN, Corbett AH, Hawke RL. Common herbal dietary supplement-drug interactions. Am Fam Physician. 2017;96(2):101–7.PubMedGoogle Scholar
  34. 34.
    Van Wyk BE. A review of commercially important African medicinal plants. J Ethnopharmacol. 2015;176:118–34.  https://doi.org/10.1016/j.jep.2015.10.031.CrossRefPubMedGoogle Scholar
  35. 35.
    Tam SW, Worcel M, Wyllie M. Yohimbine: a clinical review. Pharmacol Ther. 2001;91(3):215–43.CrossRefPubMedGoogle Scholar
  36. 36.
    Bancroft J. The endocrinology of sexual arousal. The Journal of endocrinology. 2005;186(3):411–27.  https://doi.org/10.1677/joe.1.06233.CrossRefPubMedGoogle Scholar
  37. 37.
    Prieto D. Physiological regulation of penile arteries and veins. International journal of impotence research. 2008;20(1):17–29.  https://doi.org/10.1038/sj.ijir.3901581.CrossRefPubMedGoogle Scholar
  38. 38.
    Saenz de Tejada I, Kim NN, Goldstein I, Traish AM. Regulation of pre-synaptic alpha adrenergic activity in the corpus cavernosum. Int J Impot Res. 2000;12(Suppl 1):S20–5.CrossRefPubMedGoogle Scholar
  39. 39.
    Musicki B, Burnett AL. Constitutive NOS uncoupling and NADPH oxidase upregulation in the penis of type 2 diabetic men with erectile dysfunction. Andrology. 2017;5(2):294–8.  https://doi.org/10.1111/andr.12313.CrossRefPubMedPubMedCentralGoogle Scholar
  40. 40.
    Rodrigues FL, Fais RS, Pereira M, Garcia-Cairasco N, Tostes RC, Carneiro FS. Erectile dysfunction in Wistar audiogenic rats is associated with increased cavernosal contraction and decreased neuronal nitric oxide synthase protein expression. Urology. 2017;106:237.e1-.e8.  https://doi.org/10.1016/j.urology.2017.04.048.CrossRefGoogle Scholar
  41. 41.
    Rowland DL, McNabney SM, Mann AR. Sexual function, obesity, and weight loss in men and women. Sex Med Rev. 2017;5(3):323–38.  https://doi.org/10.1016/j.sxmr.2017.03.006.CrossRefPubMedGoogle Scholar
  42. 42.
    Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother. 2010;44(6):1022–9.  https://doi.org/10.1345/aph.1P060.CrossRefPubMedGoogle Scholar
  43. 43.
    Giampreti A, Lonati D, Locatelli C, Rocchi L, Campailla MT. Acute neurotoxicity after yohimbine ingestion by a body builder. Clin Toxicol (Phila). 2009;47(8):827–9.  https://doi.org/10.1080/15563650903081601.CrossRefPubMedGoogle Scholar
  44. 44.
    Liyanage CR, Kodali V. Bulk muscles, loose cables. BMJ Case Rep. 2014;2014:bcr2014204424.  https://doi.org/10.1136/bcr-2014-204424.CrossRefPubMedPubMedCentralGoogle Scholar
  45. 45.
    Corazza O, Martinotti G, Santacroce R, Chillemi E, Di Giannantonio M, Schifano F, et al. Sexual enhancement products for sale online: raising awareness of the psychoactive effects of yohimbine, maca, horny goat weed, and Ginkgo biloba. BioMed Res Int. 2014;2014:841798–13.  https://doi.org/10.1155/2014/841798.CrossRefPubMedPubMedCentralGoogle Scholar
  46. 46.
    Clark JT, Smith ER, Davidson JM. Enhancement of sexual motivation in male rats by yohimbine. Science. 1984;225(4664):847–9.CrossRefPubMedGoogle Scholar
  47. 47.
    Ernst E, Pittler MH. Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials. J Urol. 1998;159(2):433–6.CrossRefPubMedGoogle Scholar
  48. 48.
    Morales A, Condra M, Owen JA, Surridge DH, Fenemore J, Harris C. Is yohimbine effective in the treatment of organic impotence? Results of a controlled trial. J Urol. 1987;137(6):1168–72.CrossRefPubMedGoogle Scholar
  49. 49.
    Smith ER, Lee RL, Schnur SL, Davidson JM. Alpha 2-adrenoceptor antagonists and male sexual behavior: I. Mating behavior. Physiol Behav. 1987;41(1):7–14.CrossRefPubMedGoogle Scholar
  50. 50.
    Senbel AM, Mostafa T. Yohimbine enhances the effect of sildenafil on erectile process in rats. International journal of impotence research. 2008;20(4):409–17.  https://doi.org/10.1038/sj.ijir.3901630.CrossRefPubMedGoogle Scholar
  51. 51.
    Saad MA, Eid NI, Abd El-Latif HA, Sayed HM. Potential effects of yohimbine and sildenafil on erectile dysfunction in rats. European journal of pharmacology. 2013;700(1-3):127–33.  https://doi.org/10.1016/j.ejphar.2012.12.020.CrossRefPubMedGoogle Scholar
  52. 52.
    Carro-Juarez M, Rodriguez-Manzo G. Alpha-adrenergic agents modulate the activity of the spinal pattern generator for ejaculation. International journal of impotence research. 2006;18(1):32–8.  https://doi.org/10.1038/sj.ijir.3901393.CrossRefPubMedGoogle Scholar
  53. 53.
    Carro-Juareza M, Rodriguez-Manzo G. Yohimbine reverses the exhaustion of the coital reflex in spinal male rats. Behav Brain Res. 2003;141(1):43–50.CrossRefPubMedGoogle Scholar
  54. 54.
    Chehensse C, Facchinetti P, Bahrami S, Andrey P, Soler JM, Chretien F, et al. Human spinal ejaculation generator. Ann Neurol. 2017;81(1):35–45.  https://doi.org/10.1002/ana.24819.CrossRefPubMedGoogle Scholar
  55. 55.
    Piletz JE, Segraves KB, Feng YZ, Maguire E, Dunger B, Halaris A. Plasma MHPG response to yohimbine treatment in women with hypoactive sexual desire. J Sex Marital Ther. 1998;24(1):43–54.  https://doi.org/10.1080/00926239808414668.CrossRefPubMedGoogle Scholar
  56. 56.
    Meston CM, Worcel M. The effects of yohimbine plus L-arginine glutamate on sexual arousal in postmenopausal women with sexual arousal disorder. Arch Sex Behav. 2002;31(4):323–32.CrossRefPubMedGoogle Scholar
  57. 57.
    Michelson D, Kociban K, Tamura R, Morrison MF. Mirtazapine, yohimbine or olanzapine augmentation therapy for serotonin reuptake-associated female sexual dysfunction: a randomized, placebo controlled trial. J Psychiatr Res. 2002;36(3):147–52.CrossRefPubMedGoogle Scholar
  58. 58.
    Abebe W. Herbal medication: potential for adverse interactions with analgesic drugs. J Clin Pharm Ther. 2002;27(6):391–401.CrossRefPubMedGoogle Scholar
  59. 59.
    Bressler R. Herb-drug interactions. Interactions between saw palmetto and prescription medications. Geriatrics. 2005;60(11):32 4.PubMedGoogle Scholar
  60. 60.
    Ciocon JO, Ciocon DG, Galindo DJ. Dietary supplements in primary care. Botanicals can affect surgical outcomes and follow-up. Geriatrics. 2004;59(9):20–4.PubMedGoogle Scholar
  61. 61.
    Bussmann RW, Paniagua Zambrana NY, Romero C, Hart RE. Astonishing diversity-the medicinal plant markets of Bogota, Colombia. J Ethnobiol Ethnomed. 2018;14(1):43.  https://doi.org/10.1186/s13002-018-0241-8.CrossRefPubMedPubMedCentralGoogle Scholar
  62. 62.
    Rowland D, Motofei I, Popa F, Constantin V, Vasilache A. The postfinasteride syndrome: an overview. J Mind Med Sci. 2016;3(2):99–107.Google Scholar
  63. 63.
    Rowland D. Culture and the Practice of Sexual Medicine. In: Rowland DL, EA J, editors. Cultural differences and the practice of sexual medicine. Switzerland: Springer Nature; In Press.Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • David L. Rowland
    • 1
    Email author
  • Sean M. McNabney
    • 1
  • Allyse M. Donarski
    • 1
  1. 1.Department of PsychologyValparaiso UniversityValparaisoUSA

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