Current Sexual Health Reports

, Volume 10, Issue 3, pp 158–168 | Cite as

Opioid-Related Sexual Dysfunction in Men

  • Catherine T. Nguyen
  • Justin La
  • Faysal A. YafiEmail author
Male Sexual Dysfunction and Disorders (AW Pastuszak and NK Gupta, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Male Sexual Dysfunction and Disorders


Purpose of Review

Opioids are the cornerstone for pain treatment with significant recent increases in the number of prescriptions. Sexual dysfunction (SD) is a major side effect of opioid therapy. The goal of this review is to examine the current literature on the effects of opioids on male SD (erectile dysfunction [ED], hypogonadism, ejaculatory dysfunction) and infertility.

Recent Findings

High prevalence of SD exists in men with opioid use as compared to the general population, with an abundance of evidence suggesting an association between opioid use and ED and hypogonadism. There appears to be a role for testosterone replacement therapy for hypogonadism in men on opioid therapy. Screening for low testosterone levels is recommended in men on opioid therapy with signs and symptoms of androgen deficiency. Data on fertility, ejaculatory, and orgasmic dysfunction are limited.


SD is significantly affected by opioid therapy in men. Data demonstrate the benefits of screening for SD and treatment for hypogonadism.


Opioid Sexual dysfunction Erectile dysfunction Ejaculatory dysfunction Premature ejaculation Opioid induced androgen deficiency (OPIAD) 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Catherine T. Nguyen
    • 1
  • Justin La
    • 1
  • Faysal A. Yafi
    • 1
    Email author
  1. 1.Department of UrologyUniversity of CaliforniaOrangeUSA

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