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Current Sexual Health Reports

, Volume 10, Issue 3, pp 169–176 | Cite as

What Is the Future of Erectile Dysfunction Therapy?

  • Jeffrey D. Campbell
  • Uros Milenkovic
  • Maarten Albersen
  • Trinity J. Bivalacqua
Male Sexual Dysfunction and Disorders (AW Pastuszak and NK Gupta, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Male Sexual Dysfunction and Disorders

Abstract

Purpose of Review

Erectile dysfunction (ED) is a burden for the majority of men during their lifetime. Phosphodiesterase type-5 inhibitors are first-line treatment for men with ED; however, they are limited by on-demand dosing, short-term benefits, and reduced efficacy in difficult to treat populations such as men with diabetes mellitus or ED after radical prostatectomy.

Recent Findings

Novel treatment options that offer a durable, tissue restorative approaches are being explored and potentially offer a long-term solution to this medical affliction. Medical therapies such as nanoparticles and botulinum neurotoxin, new technology including vibratory devices and low-intensity extracorporeal shockwave treatment, and regenerative medicine approaches that are undergoing human clinical trials.

Summary

Although preclinical data surrounding novel ED therapies are intriguing, these studies are not yet robust enough to support these endeavors outside of clinical trials and further work is ongoing.

Keywords

Erectile dysfunction Low-intensity extracorporeal shockwave treatment Phosphodiesterase-5 inhibitors Stem cell therapy Platelet-rich plasma Nanoparticles 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Jeffrey D. Campbell
    • 1
  • Uros Milenkovic
    • 2
  • Maarten Albersen
    • 2
  • Trinity J. Bivalacqua
    • 1
  1. 1.The James Buchanan Brady Urological Institute and Department of Urologythe Johns Hopkins School of MedicineBaltimoreUSA
  2. 2.Laboratory of Experimental Urology, Department of Development and RegenerationCatholic University of LeuvenLeuvenBelgium

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