Chlamydia-Induced Reactive Arthritis: Disappearing Entity or Lack of Research?

  • Henning ZeidlerEmail author
  • Alan P. Hudson
Infection and Arthritis (K Winthrop, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Infections and Arthritis


Purpose of Review

Recent studies regarding the frequency of Chlamydia-induced reactive arthritis (ReA) are reviewed, with a focus on the question of whether the entity is in fact disappearing or whether it is simply being underdiagnosed/underreported. Epidemiological reports indicate diversity in the frequency of Chlamydia-associated ReA in various parts of the world, with evidence of declining incidence in some regions.

Recent Findings

The hypothesis that early effective treatment with antibiotics prevents the manifestation of Chlamydia-associated ReA requires further investigation.


For clinicians, it is important to remember that ReA secondary to Lymphogranuloma venereum (LGV) serovars L1–L3 of C. trachomatis is probably underestimated due to a limited awareness of this condition, the re-emergence in Western countries of LGV overall, and the present increasingly rare classical inguinal presentation.


Reactive arthritis Chlamydia trachomatis Chlamydia pneumoniae Epidemiology Lymphogranuloma venereum 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Hannover Medical SchoolHannoverGermany
  2. 2.School of MedicineWayne State UniversityDetroitUSA

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