Transdermal Lidocaine for Perioperative Pain: a Systematic Review of the Literature

  • Jordan Smoker
  • Alexa Cohen
  • Mohammad R. Rasouli
  • Eric S. SchwenkEmail author
Other Pain (A Kaye and N Vadivelu, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Other Pain


Purpose of Review

The purpose of this review is to provide a summary of the perioperative studies that have examined transdermal lidocaine (lidocaine patch) as an analgesic and put the evidence in context of the likely overall benefit of transdermal lidocaine in the perioperative period.

Recent Findings

Several randomized controlled trials have been published in the past 4 years that concluded transdermal lidocaine can reduce acute pain associated with laparoscopic trocar or cannula insertion.


Transdermal lidocaine may reduce short-term pain after surgery in selected surgery types and has a low risk of toxicity but its overall clinical utility in the perioperative setting is questionable. Transdermal lidocaine does not consistently reduce opioid consumption after surgery and has not been shown to improve patient function.


Transdermal lidocaine Lidocaine patch Perioperative analgesia Multimodal analgesia Local anesthetics Opioid epidemic 


Funding Information

Departmental funds only.

Compliance with Ethical Standards

Conflict of Interest

The authors declare no conflicts of interest relevant to this manuscript.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Supplementary material

11916_2019_830_MOESM1_ESM.pdf (631 kb)
ESM 1 (PDF 630 kb)


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Jordan Smoker
    • 1
  • Alexa Cohen
    • 2
  • Mohammad R. Rasouli
    • 3
  • Eric S. Schwenk
    • 1
    Email author
  1. 1.Department of AnesthesiologySidney Kimmel Medical College at Thomas Jefferson UniversityPhiladelphiaUSA
  2. 2.Sidney Kimmel Medical College at Thomas Jefferson UniversityPhiladelphiaUSA
  3. 3.Department of Anesthesiology, Perioperative and Pain Medicine, Division of Pain MedicineStanford University HospitalPalo AltoUSA

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