Bone Marrow Adipose Tissue Quantification by Imaging

  • Ebrahim Bani Hassan
  • Ali Ghasem-Zadeh
  • Mahdi Imani
  • Numan Kutaiba
  • David K. Wright
  • Tara Sepehrizadeh
  • Gustavo DuqueEmail author
Bone Marrow and Adipose Tissue (G Duque and B Lecka-Czernik, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Bone Marrow and Adipose Tissue


Purpose of Review

The significance and roles of marrow adipose tissue (MAT) are increasingly known, and it is no more considered a passive fat storage but a tissue with significant paracrine and endocrine activities that can cause lipotoxicity and inflammation.

Recent Findings

Changes in the MAT volume and fatty acid composition appear to drive bone and hematopoietic marrow deterioration, and studying it may open new horizons to predict bone fragility and anemia development. MAT has the potential to negatively impact bone volume and strength through several mechanisms that are partially described by inflammaging and lipotoxicity terminology.


Evidence indicates paramount importance of MAT in age-associated decline of bone and red marrow structure and function. Currently, MAT measurement is being tested and validated by several techniques. However, purpose-specific adaptation of existing imaging technologies and, more importantly, development of new modalities to quantitatively measure MAT are yet to be done.


Yellow marrow Osteosarcopenia Red marrow Hematopoietic marrow Lipotoxicity CT MRI 


Compliance with Ethical Standards

Conflict of Interest

Ebrahim Bani Hassan, Ali Ghasem-Zadeh, Mahdi Imani, Numan Kutaiba, David K Wright, Tara Sepehrizadeh, and Gustavo Duque declare no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Ebrahim Bani Hassan
    • 1
    • 2
  • Ali Ghasem-Zadeh
    • 1
    • 3
  • Mahdi Imani
    • 1
    • 2
  • Numan Kutaiba
    • 4
  • David K. Wright
    • 5
  • Tara Sepehrizadeh
    • 6
  • Gustavo Duque
    • 1
    • 2
    Email author
  1. 1.Australian Institute for Musculoskeletal Science (AIMSS)The University of Melbourne and Western HealthSt. AlbansAustralia
  2. 2.Department of Medicine-Western HealthThe University of MelbourneSt. AlbansAustralia
  3. 3.Department of Medicine and EndocrinologyAustin HealthMelbourneAustralia
  4. 4.Austin Health, Department of RadiologyHeidelbergAustralia
  5. 5.Department of Neuroscience, Central Clinical SchoolMonash UniversityMelbourneAustralia
  6. 6.Monash Biomedical ImagingMonash UniversityMelbourneAustralia

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