Osteoglycin and Bone—a Systematic Review

  • Jakob Starup-LindeEmail author
  • Rikke Viggers
  • Aase Handberg
Bone and Diabetes (A Schwartz and P Vestergaard, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Bone and Diabetes


Purpose of Review

Bone turnover is a regulated process. Osteoglycin is suggested to have an important impact on bone function but may also affect cardiovascular and metabolic functions. This review investigates the action of osteoglycin in bone as well as its potential endocrine effects.

Recent Findings

Osteoglycin is expressed by several tissues including bone and muscle. Some studies suggest that osteoglycin increases osteoblast differentiation whereas others suggest that osteoglycin decreases osteoblast differentiation. Thus, findings on the influence of osteoglycin in bone are conflicting. A recent study found increased bone mass in osteoglycin deficient mice. Another study reported that osteoglycin is a marker of low bone mineral density and vertebral fractures in women with type 2 diabetes. Furthermore, clinical studies link osteoglycin to insulin resistance and cardiovascular disease.


Osteoglycin may be a novel marker of a muscle, pancreatic, and bone axis. However, current evidence is limited and further research investigating osteoglycin in both a pre-clinical and a clinical setting is needed.


Bone Osteoglycin Insulin resistance Bone turnover 


Compliance with Ethical Standards

Conflict of Interest

Jakob Starup-Linde reports personal fees from Gilead Sciences Denmark and Eli Lilly Denmark.

Rikke Viggers and Aase Handberg declare no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Jakob Starup-Linde
    • 1
    • 2
    Email author
  • Rikke Viggers
    • 3
  • Aase Handberg
    • 4
    • 5
  1. 1.Department of MedicineHorsens Regional HospitalHorsensDenmark
  2. 2.Department of Endocrinology and Internal MedicineAarhus University HospitalAarhusDenmark
  3. 3.Department of EndocrinologyAalborg University HospitalAalborgDenmark
  4. 4.Department of Clinical BiochemistryAalborg University HospitalAalborgDenmark
  5. 5.Department of Clinical Medicine, The Faculty of MedicineAalborg UniversityAalborgDenmark

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