Impact of Induced Pluripotent Stem Cells in Bone Repair and Regeneration
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Purpose of Review
The main objective of this article is to investigate the current trends in the use of induced pluripotent stem cells (iPSCs) for bone tissue repair and regeneration.
Pluripotent stem cell–based tissue engineering has extended innovative therapeutic approaches for regenerative medicine. iPSCs have shown osteogenic differentiation capabilities and would be an innovative resource of stem cells for bone tissue regenerative applications.
This review recapitulates the current knowledge and recent progress regarding utilization of iPSCs for bone therapy. A review of current findings suggests that a combination of a three-dimensional scaffolding system with iPSC technology to mimic the physiological complexity of the native stem cell niche is highly favorable for bone tissue repair and regeneration.
KeywordsInduced pluripotent stem cells (iPSCs) Biomaterials Osteogenic differentiation Bone tissue engineering Bone regeneration
Compliance with Ethical Standards
Conflict of Interest
Deepti Rana, Sanjay Kumar, Thomas J. Webster, and Murugan Ramalingam declare no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance
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