Current Osteoporosis Reports

, Volume 17, Issue 4, pp 226–234 | Cite as

Impact of Induced Pluripotent Stem Cells in Bone Repair and Regeneration

  • Deepti Rana
  • Sanjay Kumar
  • Thomas J. WebsterEmail author
  • Murugan RamalingamEmail author
Regenerative Biology and Medicine in Osteoporosis (S Bryant and M Krebs, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Regenerative Biology and Medicine in Osteoporosis


Purpose of Review

The main objective of this article is to investigate the current trends in the use of induced pluripotent stem cells (iPSCs) for bone tissue repair and regeneration.

Recent Findings

Pluripotent stem cell–based tissue engineering has extended innovative therapeutic approaches for regenerative medicine. iPSCs have shown osteogenic differentiation capabilities and would be an innovative resource of stem cells for bone tissue regenerative applications.


This review recapitulates the current knowledge and recent progress regarding utilization of iPSCs for bone therapy. A review of current findings suggests that a combination of a three-dimensional scaffolding system with iPSC technology to mimic the physiological complexity of the native stem cell niche is highly favorable for bone tissue repair and regeneration.


Induced pluripotent stem cells (iPSCs) Biomaterials Osteogenic differentiation Bone tissue engineering Bone regeneration 


Compliance with Ethical Standards

Conflict of Interest

Deepti Rana, Sanjay Kumar, Thomas J. Webster, and Murugan Ramalingam declare no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Biomechanical Engineering, Technical Medical CentreUniversity of TwenteEnschedeThe Netherlands
  2. 2.Centre for Stem Cell ResearchChristian Medical College CampusVelloreIndia
  3. 3.Department of Chemical EngineeringNortheastern UniversityBostonUSA
  4. 4.Biomaterials and Stem Cell Engineering Lab, Centre for Biomaterials, Cellular and Molecular Theranostics, School of Mechanical EngineeringVellore Institute of Technology (Deemed to be University)VelloreIndia

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