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Current Osteoporosis Reports

, Volume 17, Issue 4, pp 217–225 | Cite as

Contextual Regulation of Skeletal Physiology by Notch Signaling

  • Daniel W. YoungstromEmail author
  • Kurt D. Hankenson
Skeletal Development (R Marcucio and J Feng, Section Editors)
  • 78 Downloads
Part of the following topical collections:
  1. Topical Collection on Skeletal Development

Abstract

Purpose of Review

This article reviews the past 2 years of research on Notch signaling as it relates to bone physiology, with the goal of reconciling seemingly discrepant findings and identifying fruitful areas of potential future research.

Recent Findings

Conditional animal models and high-throughput omics have contributed to a greater understanding of the context-dependent role of Notch signaling in bone. However, significant gaps remain in our understanding of how spatiotemporal context and epigenetic state dictate downstream Notch phenotypes.

Summary

Biphasic activation of Notch signaling orchestrates progression of mesenchymal progenitor cells through the osteoblast lineage, but there is a limited understanding of ligand- and receptor-specific functions. Paracrine Notch signaling through non-osteoblastic cell types contributes additional layers of complexity, and we anticipate impactful future work related to the integration of these cell types and signaling mechanisms.

Keywords

Notch signaling Jagged-1 Bone biology Musculoskeletal metabolism Mesenchymal progenitor cells Osteoblasts 

Notes

Funding Information

Daniel Youngstrom reports grants from National Institutes of Health (F32DE026346) during the conduct of the study.

Compliance with Ethical Standards

Conflict of Interest

Kurt Hankenson reports he was co-founder of Skelegen LLC, and has received a research grant from Orthofix. Both are outside the submitted work.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Orthopaedic SurgeryUniversity of Michigan Medical SchoolAnn ArborUSA

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