PET-MRI for the Study of Metabolic Bone Disease
Purpose of Review
This review article attempts to summarize the current state and applications of the hybrid imaging modality of PET-MRI to metabolic bone diseases. The advances of PET and MRI are also discussed for metabolic bone diseases as potentially applied via PET-MRI.
Etiologies and mechanisms of metabolic bone disease can be complex where molecular changes precede structural changes. Although PET-MRI has yet to be applied directly to metabolic bone disease, possible applications exist since PET, specifically 18F-NaF PET, can quantitatively track changes in bone metabolism and is useful for assessing treatment, while MRI can give detailed information on bone water concentration, porosity, and architecture through novel techniques such as UTE and ZTE MRI.
Earlier detection and further understanding of metabolic bone disease via PET and MRI could lead to better treatment and prevention. More research using this modality is needed to further understand how it can be implemented in this realm.
KeywordsPositron emission tomography-magnetic resonance imaging (PET-MRI) Musculoskeletal diseases Metabolic bone disease Imaging
Compliance with Ethical Standards
Conflict of Interest
James Yoder, Feliks Kogan and Garry Gold report grants from GE Healthcare and the NIH during the conduct of this study.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
The authors receive research support from GE Healthcare.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
- 11.Etchebehere EC, Hobbs BP, Milton DR, Malawi O, Patel S, Benjamin RS, et al. Assessing the role of (1)(8)F-FDG PET and (1)(8)F-FDG PET/CT in the diagnosis of soft tissue musculoskeletal malignancies: a systematic review and meta-analysis. Eur J Nucl Med Mol Imaging. 2016;43:860–70.CrossRefGoogle Scholar
- 19.Uchida K, Nakajima H, Miyazaki T, et al. Effects of alendronate on bone metabolism in glucocorticoid-induced osteoporosis measured by 18F-fluoride PET: a prospective study. J Nucl Med Off Publ Soc Nucl Med. 2009;50(11):1808–14.Google Scholar
- 26.• Blake GM, Siddique M, Frost ML, Moore AE, Fogelman I. Quantitative PET imaging using 18F sodium fluoride in the assessment of metabolic bone diseases and the monitoring of their response to therapy. PET Clin. 2012;7:275–91 The article discusses how 18F-NaF PET can be used to quantify bone metabolism and monitor responses to treatments through bone plasma clearance and SUV measurements. CrossRefGoogle Scholar
- 28.• Kogan F, Fan AP, McWalter EJ, et al. PET/MRI of metabolic activity in osteoarthritis: a feasibility study. J Magn Reson Imaging. 2017;45(6):1736–45 This study demonstrates how hybrid PET-MRI can be used to detect metabolic bone abnormalities in osteoarthritis and could be applied specifically to metabolic bone diseases. CrossRefGoogle Scholar
- 30.Kogan F, Fan AP, Black M, Hargreaves B, Gold G. Imaging of bone metabolism and its spatial relationship with cartilage matrix changes in ACL-injured patients. Orthopaedic Research Society 2018 Annual meeting. New Orleans, LA 2018.Google Scholar
- 42.Agrawal K, Agarwal Y, Chopra RK, et al. Evaluation of MR spectroscopy and diffusion-weighted MRI in postmenopausal bone strength. Cureus. 2015;e327:7.Google Scholar
- 59.• Wiesinger F, Sacolick LI, Menini A, Zero TE, et al. MR bone imaging in the head. Magn Reson Med. 2016;75:107–14 This study demonstrates how zTE MRI can be used to distinguish bone and could be useful in MR-based attenuation correction of PET data, as it pertains to PET-MRI and metabolic bone diseases. CrossRefGoogle Scholar