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Current Osteoporosis Reports

, Volume 15, Issue 4, pp 247–254 | Cite as

Engineering 3D Models of Tumors and Bone to Understand Tumor-Induced Bone Disease and Improve Treatments

  • Kristin A. Kwakwa
  • Joseph P. Vanderburgh
  • Scott A. Guelcher
  • Julie A. SterlingEmail author
Cancer-induced Musculoskeletal Diseases (M Reagan and E Keller, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Cancer-induced Musculoskeletal Diseases

Abstract

Purpose of Review

Bone is a structurally unique microenvironment that presents many challenges for the development of 3D models for studying bone physiology and diseases, including cancer. As researchers continue to investigate the interactions within the bone microenvironment, the development of 3D models of bone has become critical.

Recent Findings

3D models have been developed that replicate some properties of bone, but have not fully reproduced the complex structural and cellular composition of the bone microenvironment. This review will discuss 3D models including polyurethane, silk, and collagen scaffolds that have been developed to study tumor-induced bone disease. In addition, we discuss 3D printing techniques used to better replicate the structure of bone.

Summary

3D models that better replicate the bone microenvironment will help researchers better understand the dynamic interactions between tumors and the bone microenvironment, ultimately leading to better models for testing therapeutics and predicting patient outcomes.

Keywords

3D models Bone tumors Bone 3D printing Tumor microenvironment 

Notes

Acknowledgements

This work was supported by 1I01BX001957 (JAS), 1R01CA163499 (SAG/JAS), 5R01 AR064772 (SAG), and 5T32CA009592 (KAK).

Compliance with Ethical Standards

Conflict of Interest

Kristin Kwakwa, Joseph Vanderburgh, Julie Sterling, and Scott Guelcher declare no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

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Copyright information

© Springer Science+Business Media, LLC (outside the USA) 2017

Authors and Affiliations

  • Kristin A. Kwakwa
    • 1
    • 2
    • 3
  • Joseph P. Vanderburgh
    • 1
    • 2
    • 4
  • Scott A. Guelcher
    • 2
    • 4
    • 5
    • 6
  • Julie A. Sterling
    • 1
    • 2
    • 3
    • 5
    • 6
    Email author
  1. 1.Department of Veterans AffairsTennessee Valley Healthcare SystemNashvilleUSA
  2. 2.Vanderbilt Center for Bone BiologyVanderbilt University Medical CenterNashvilleUSA
  3. 3.Department of Cancer BiologyVanderbilt UniversityNashvilleUSA
  4. 4.Department of Chemical and Biomolecular EngineeringVanderbilt UniversityNashvilleUSA
  5. 5.Department of Biomedical EngineeringVanderbilt UniversityNashvilleUSA
  6. 6.Department of Medicine, Division of Clinical PharmacologyVanderbilt University Medical CenterNashvilleUSA

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