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Current Osteoporosis Reports

, Volume 15, Issue 4, pp 385–395 | Cite as

Osteomacs and Bone Regeneration

  • Lena Batoon
  • Susan Marie Millard
  • Liza Jane Raggatt
  • Allison Robyn PettitEmail author
Osteoimmunology (MB Humphrey and M Nakamura, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Osteoimmunology

Abstract

Purpose of Review

Mounting evidence supporting the critical contribution of macrophages, in particular osteal macrophages, to bone regeneration is reviewed. We specifically examine the potential role of macrophages in the basic multicellular units coordinating lifelong bone regeneration via remodelling and bone regeneration in response to injury. We review and discuss the distinctions between macrophage and osteoclast contributions to bone homeostasis, particularly the dichotomous role of the colony-stimulating factor 1—colony-stimulating factor 1 receptor axis.

Recent Findings

The impact of inflammation associated with aging and other hallmarks of aging, including senescence, on macrophage function is addressed in the context of osteoporosis and delayed fracture repair. Resident macrophages versus recruited macrophage contributions to fracture healing are also discussed.

Summary

We identify some of the remaining knowledge gaps that will need to be closed in order to maximise benefits from therapeutically modulating or mimicking the function of macrophages to improve bone health and regeneration over a lifetime.

Keywords

Macrophages Bone regeneration Fracture repair Senescence Inflammaging Osteoporosis 

Notes

Acknowledgements

This work was supported by the Mater Foundation and an Australian and New Zealand Bone and Mineral Society Gap Fellowship to ARP.

Dr. Andy C. Wu contributed to experiments in Fig. 1.

Compliance with Ethical Standards

Conflict of Interest

Lena Batoon, Allison Pettit, Liza Jane Raggatt and Susan Millard declare no conflict of interest.

Human and Animal Rights and Informed Consent

All reported studies/experiments with human or animal subjects performed by the authors comply with all applicable ethical standards (including the Helsinki Declaration and its amendments, institutional/national research committee standards and international/national/institutional guidelines). Animal experiments were approved by The University of Queensland Health Sciences Ethics Committee and performed in accordance with the Australian Code of Practice for the Care and Use of Animals for Scientific Purposes.

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Lena Batoon
    • 1
  • Susan Marie Millard
    • 1
  • Liza Jane Raggatt
    • 1
    • 2
  • Allison Robyn Pettit
    • 1
    • 2
    Email author
  1. 1.Bones and Immunology Laboratory, Cancer Biology and Care ProgramMater Research Institute - The University of Queensland, Translational Research InstituteWoolloongabbaAustralia
  2. 2.Faculty of MedicineThe University of QueenslandHerstonAustralia

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