Current Osteoporosis Reports

, Volume 15, Issue 4, pp 367–375 | Cite as

Osteoimmunology in Bone Fracture Healing

  • Takehito Ono
  • Hiroshi TakayanagiEmail author
Osteoimmunology (M Humphrey and M Nakamura, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Osteoimmunology


Purpose of Review

In the process of bone fracture healing, inflammation is thought to be an essential process that precedes bone formation and remodeling. We review recent studies on bone fracture healing from an osteoimmunological point of view.

Recent Findings

Based on previous observations that many types of immune cells infiltrate into the bone injury site and release a variety of molecules, recent studies have addressed the roles of specific immune cell subsets. Macrophages and interleukin (IL)-17-producing γδ T cells enhance bone healing, whereas CD8+ T cells impair bone repair. Additionally, IL-10-producing B cells may contribute to bone healing by suppressing excessive and/or prolonged inflammation. Although the involvement of other cells and molecules has been suggested, the precise underlying mechanisms remain elusive.


Accumulating evidence has begun to reveal the deeper picture of bone fracture healing. Further studies are required for the development of novel therapeutic strategies for bone fracture.


Bone repair Inflammation γδ T cell Cytokine Bone formation Osteoblast 


Compliance with Ethical Standards

Conflicts of Interest

Hiroshi Takayanagi reports grants from the Japan Science and Technology Agency, Japan Society for the Promotion of Science, Chugai Pharmaceutical Co., AYUMI Pharmaceutical Corporation, and Noevir, outside the submitted work. Takehito Ono reports grants from the Japan Society for the Promotion of Science, and The Ministry of Education, Culture, Sports, Science and Technology of Japan, during the conduct of the study, and grants from The Ichiro Kanehara Foundation outside the submitted work.

Human and Animal Rights and Informed Consent

Reference 29 is presented by the 1st and the corresponding author and used animal subject (mice).

All the experiments in the paper were performed with the approval of the Institutional Review Board at the University of Tokyo.


Papers of particular interest, published recently, have been highlighted as: •Of importance ••Of major importance

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Department of Cell Signaling, Graduate School of Medical and Dental SciencesTokyo Medical and Dental University (TMDU)TokyoJapan
  2. 2.Department of Immunology, Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan

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