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Current Osteoporosis Reports

, Volume 15, Issue 4, pp 318–325 | Cite as

Osteocyte Mechanobiology

  • Yuhei Uda
  • Ehab Azab
  • Ningyuan Sun
  • Chao Shi
  • Paola Divieti PajevicEmail author
Osteocytes (T Bellido and J Klein-Nulend, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Osteocytes

Abstract

Purpose of Review

Over the past decades, osteocytes have emerged as mechano-sensors of bone and master regulators of bone homeostasis. This article summarizes latest research and progress made in understanding osteocyte mechanobiology and critically reviews tools currently available to study these cells.

Recent Findings

Whereas increased mechanical forces promote bone formation, decrease loading is always associated with bone loss and skeletal fragility. Recent studies identified cilia, integrins, calcium channels, and G-protein coupled receptors as important sensors of mechanical forces and Ca2+ and cAMP signaling as key effectors. Among transcripts regulated by mechanical forces, sclerostin and RANKL have emerged as potential therapeutic targets for disuse-induced bone loss.

Summary

In this paper, we review the mechanisms by which osteocytes perceive and transduce mechanical cues and the models available to study mechano-transduction. Future directions of the field are also discussed.

Keywords

Osteocyte Mechanical forces Sclerostin Bone homeostasis 

Notes

Compliance with Ethical Standards

Conflict of Interest

Yuhei Uda, Chao Shi, Ehab Azab, and Ningyuan Sun declare no conflict of interest.

Divieti Pajevic reports grants from NIH/NIAMS during the conduct of the study.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Yuhei Uda
    • 1
  • Ehab Azab
    • 1
  • Ningyuan Sun
    • 1
  • Chao Shi
    • 1
    • 2
  • Paola Divieti Pajevic
    • 1
    • 3
    Email author
  1. 1.Molecular and Cell BiologyBoston University Henry M. Goldman School of Dental MedicineBostonUSA
  2. 2.Department of OrthopaedicsThe Second Affiliated Hospital of Xi’an Jiaotong UniversityShaanxi ProvincePeople’s Republic of China
  3. 3.BostonUSA

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