Current Oncology Reports

, 21:99 | Cite as

Contemporary Approach to Locally Advanced Oral Cavity Squamous Cell Carcinoma

  • Christopher M. K. L. YaoEmail author
  • Edward I. ChangEmail author
  • Stephen Y. LaiEmail author
Head and Neck Cancers (EY Hanna, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Head and Neck Cancers


Purpose of Review

Surgical management of locally advanced oral cavity squamous cell carcinomas (OCSCC) has long been recognized as a primary treatment modality. Technological advances have led to significant improvements in our surgical approach, from improvement in the visualization of tumors to more efficient and precise reconstruction. Here, we review the latest technological advances in surgical extirpation and reconstruction of locally advanced OCSCCs.

Recent Findings

The focus of technological innovation in surgical extirpation has been on improving visualization, with the use of intraoperative ultrasound for margin delineation, intraoperative navigation, narrow-band imaging, and the use of fluorescence. Though early, these are promising steps to ensuring complete resection of the cancer. Advances in reconstruction have been centered on the incorporation of computer assisted design, manufacturing, and virtual surgical planning, allowing for more complex three-dimensional defects to be expeditiously reconstructed.


As these technologies are still under development, their impact on oncologic outcomes are not yet robustly defined; however, as technology continues to advance and become more widely available, new technologies will undoubtedly become integrated into enhancing surgical precision and planning.


Advanced oral cavity carcinoma Oral cavity reconstruction Technology Tumor margins Image-guided surgery Virtual surgical planning 


Compliance with Ethical Standards

Conflict of Interest

Christopher M.K.L. Yao declares that he has no conflict of interest.

Edward I. Chang declares that he has no conflict of interest.

Stephen Y. Lai has received compensation from Cardinal Health for service as a consultant.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Authors and Affiliations

  1. 1.Department of Head and Neck Surgery, Division of SurgeryThe University of Texas MD Anderson Cancer CenterHoustonUSA
  2. 2.Department of Plastic Surgery, Division of SurgeryThe University of Texas MD Anderson Cancer CenterHoustonUSA

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