Current Oncology Reports

, 21:88 | Cite as

New Directions in Vulvar Cancer Pathology

  • Anthony Williams
  • Sheeba Syed
  • Shireen Velangi
  • Raji GanesanEmail author
Gynecologic Cancers (NS Reed, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Gynecologic Cancers


Purpose of Review

The aim of this article is to provide clinicians and pathologists with an understanding of the aetiopathology, pathogenesis and classification of vulval neoplasia and their molecular correlates.

Recent Findings

There is an increased understanding of subcellular changes in vulvar malignancies. These provide the direction for further research and aid personalised treatment for patients.


The article explores concepts of the aetiology of vulvar cancer and updates the reader with the equivalence of terminology of preneoplastic vulval disease. The differential diagnosis of squamous neoplasia and their clinicopathological correlation is detailed. The salient findings from recent literature into the understanding of the disease of squamous cell neoplasia and rare vulvar malignancies are summarised.


Vulvar cancer Vulvar intraepithelial neoplasia (VIN) Lichen sclerosus Human papilloma virus (HPV) Sentinel node biopsy 


Compliance with Ethical Standards

Conflict of Interest

Anthony Williams declares that he has no conflict of interest.

Sheeba Syed declares that she has no conflict of interest.

Shireen Velangi has received honoraria for the preparation of vulval dermatology lectures delivered during dermatology courses throughout the UK. These courses are run by Guy’s and St. Thomas’ NHS Foundation Trust, in association with the British Association of Dermatologists, University Hospitals Birmingham and Birmingham Children’s Hospital.

Raji Ganesan declares that she has no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Anthony Williams
    • 1
  • Sheeba Syed
    • 2
  • Shireen Velangi
    • 3
  • Raji Ganesan
    • 1
    Email author
  1. 1.Birmingham Women’s and Children’s NHS Foundation TrustBirminghamUK
  2. 2.Pathology DepartmentQueen Elizabeth University Hospital GlasgowGlasgowUK
  3. 3.University Hospitals Birmingham NHS Foundation TrustBirminghamUK

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