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Current Oncology Reports

, 20:99 | Cite as

Management of Locally Advanced and Metastatic Esophageal Cancer in the Older Population

  • Dara Bracken-Clarke
  • Abdul Rehman Farooq
  • Anne M. HorganEmail author
Geriatric Oncology (AR MacKenzie, Section Editor)
  • 78 Downloads
Part of the following topical collections:
  1. Topical Collection on Geriatric Oncology

Abstract

Purpose of Review

This review aims to synthesise the current literature on the management of early-stage and metastatic esophageal cancers, focusing on the older population. In particular, we aim to dissect out the elderly-specific data from the relevant trials and to discuss the issues unique to this population.

Recent Findings

While surgery is the curative modality in esophageal malignancies, the CROSS, MAGIC and FLOT trials demonstrate a clear advantage to neoadjuvant therapy (chemotherapy and chemoradiotherapy). These trials, however, included few elderly patients. There is a similar lack of elderly-specific data in the metastatic setting.

Summary

Esophageal malignancies remain highly lethal with increasing incidence with age. Despite the relative lack of elderly-specific data, the fit older population appear to similarly benefit from multimodal therapy in early-stage and palliative therapy in metastatic disease.

Keywords

Cancer Oesophagus Oesophago-gastric junction Elderly Chemotherapy 

Notes

Compliance with Ethical Standards

Conflict of Interest

Dara Bracken-Clarke, Abdul Rehman Farooq, and Anne M. Horgan declare they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Dara Bracken-Clarke
    • 1
  • Abdul Rehman Farooq
    • 1
  • Anne M. Horgan
    • 1
    Email author
  1. 1.Medical Oncology DepartmentUniversity Hospital WaterfordWaterfordIreland

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