Regulation of Ion Channels by MicroRNAs and the Implication for Epilepsy
Purpose of Review
The goal of this focused review is to describe recent studies supporting a critical role of microRNAs in the regulation of ion channels and discuss the resulting implications for the modulation of neuronal excitability in epilepsy.
MicroRNA-induced silencing of ion channels has been shown in several different studies in recent years, and some of these reports suggest a prominent role in epilepsy. The ion channels regulated by microRNAs include ligand- and voltage-gated channels and are not only limited to the central nervous system but have also been found in the peripheral nervous system.
Ion channel-targeting microRNAs can regulate the intrinsic excitability of neurons, and thus influence entire networks in the brain. Their dysregulation in epilepsy may contribute to the disease phenotype. More research is needed to better understand the molecular mechanisms of how microRNAs regulate ion channels to control neuronal excitability, and how these processes are altered in epilepsy.
KeywordsmicroRNA Ion channels Epilepsy Neuronal excitability microRNA therapeutics Dendritic translation
Christina Gross’ and Durgesh Tiwari’s epilepsy- and microRNA-related work are supported by the NIH (R01NS092705 to C.G.) and a postdoctoral fellowship from the American Epilepsy Society (to D.T.).
Compliance with Ethical Standards
Conflict of Interest
Durgesh Tiwari declares no conflict of interest.
Christina Gross is co-inventor on US Patent No. 9932585.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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