Ureaplasma urealyticum: the Role as a Pathogen in Women’s Health, a Systematic Review

  • Hanna Hershko Kletzel
  • Reut Rotem
  • Moshe Barg
  • Jennia Michaeli
  • Orna ReichmanEmail author
Female Genital Tract Infections (J Sobel, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Female Genital Tract Infections


Purpose of Review

To evaluate the role of Ureaplasma urealyticum as a genital pathogen in women’s health. Three aspects were analyzed: (1) preterm delivery (PTD); (2) female infertility; and (3) lower genital tract pathology including pelvic inflammatory disease (PID), cervicitis, and genital discomfort (discharge, burning).

Recent Findings

A systematic review was performed. Searching PUBMED and EMBASE for published articles from January 2003 to September 2017 using the key word “Ureaplasma urealyticum” yielded 1835 manuscripts. These were further screened using defined inclusion criteria: (1) original peer-reviewed observational studies; (2) English language; (3) U. urealyticum was specifically isolated; (4) present “cases”/“exposed” and “controls”/“unexposed” to enable calculating an association between U. urealyticum and the outcome studied. Altogether, 32 studies were included that underwent quality scoring based on methodology, sample size, study population, and method of identification of U. urealyticum. The association of U. urealyticum and PTD was inconsistent between the studies. Eight of the ten prospective studies failed to show an association between U. urealyticum and PTD, yet four of the six case control studies found a positive association. Regarding female infertility and genital discomfort, five of the six studies for each of these topics failed to find an association. Only two studies met the inclusion criteria for cervicitis with conflicting conclusions. Unfortunately, none of the studies met the inclusion criteria for PID.


It seems that U. urealyticum has a limited role as a pathogen in female infertility, cervicitis, PID, and genital discomfort. The role as a pathogen in PTD is unclear and future studies are needed to address this issue.


Ureaplasma Urealyticum Preterm delivery Female infertility Cervicitis Pelvic inflammatory disease Genital discomfort 



We would like to thank Iris Arad PhD Head of Shaare Zedek Medical Center Library for her help.

Compliance with Ethical Standards

Conflict of Interest

Hanna Hershko Kletzel, Reut Rotem, Moshe Barg, Jennia Michaeli, and Orna Reichman declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Hanna Hershko Kletzel
    • 1
  • Reut Rotem
    • 1
  • Moshe Barg
    • 1
  • Jennia Michaeli
    • 1
  • Orna Reichman
    • 1
    Email author
  1. 1.Department of Obstetrics and Gynecology, Shaare Zedek Medical CenterHebrew UniversityJerusalemIsrael

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