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Alcohol and Hypertension—New Insights and Lingering Controversies

  • Ian B. PuddeyEmail author
  • Trevor A. Mori
  • Anne E. Barden
  • Lawrence J. Beilin
NUTRITION AND HYPERTENSION (T MORI, SECTION EDITOR)
  • 43 Downloads
Part of the following topical collections:
  1. Topical Collection on Nutrition and Hypertension

Abstract

Purpose of Review

To examine outstanding issues in the relationship of alcohol to hypertension. These include whether the increase in BP with alcohol is causally related, the nature of the relationship in women, the contribution of alcohol-related increases in BP to cardiovascular disease and the aetiology of alcohol-related hypertension.

Recent Findings

Intervention studies and Mendelian randomisation analyses confirm the alcohol–BP relationship is causal. The concept that low-level alcohol intake reduces BP in women is increasingly unsustainable. Alcohol-related hypertension is in the causal pathway between alcohol use and increased risk for several cardiovascular outcomes. The aetiology of alcohol-related hypertension is multifactorial with recent data highlighting the effects of alcohol on the vasoconstrictor 20-HETE and oxidative stress.

Summary

The high prevalence of both alcohol use and hypertension mandates a careful alcohol history in every patient with elevated BP. Early intervention for excessive alcohol use offers the promise of lower levels of BP and reduced risk of adverse cardiovascular outcomes.

Keywords

Alcohol Blood pressure Hypertension 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare no conflicts of interest relevant to this manuscript.

Human and Animal Rights and Informed Consent

All reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki declaration and its amendments, institutional/national research committee standards, and international/national/institutional guidelines).

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Ian B. Puddey
    • 1
    Email author
  • Trevor A. Mori
    • 1
  • Anne E. Barden
    • 1
  • Lawrence J. Beilin
    • 1
  1. 1.Medical School, Faculty of Medical and Health SciencesUniversity of Western AustraliaPerthAustralia

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