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Current Hypertension Reports

, 21:69 | Cite as

A Review of Angiogenic Imbalance in HIV-Infected Hypertensive Disorders of Pregnancy

  • Sayuri PadayacheeEmail author
  • Jagidesa Moodley
  • Thajasvarie Naicker
Preeclampsia (V Garovic, Section Editor)
  • 31 Downloads
Part of the following topical collections:
  1. Topical Collection on Preeclampsia

Abstract

Purpose of Review

This review provides a comprehensive insight into the angiogenic profile of hypertensive and normotensive pregnancies compromised by HIV infection. Furthermore, we evaluate the economic implementation of the sFlt-1/PlGF ratio and review the reports on therapeutic apheresis in limiting sFlt-1 production.

Recent Findings

In preeclampsia, an increased expression of sFlt-1 triggers angiogenic imbalance. Women of African ancestry have high levels of angiogenic factors than other racial groups. The sFlt-1/PlGF ratio shows promise in the early assessment of preeclampsia, while sFlt-1 apheresis restores angiogenic imbalance. Studies suggest antiretroviral therapy does not impact the angiogenic shift in preeclampsia development.

Summary

The angiogenic profile in pregnant women of different races influences preeclampsia development. Despite the opposing immune response in HIV infection and preeclampsia, the HIV tat protein strongly mimics vascular endothelial growth factor (VEGF); hence, it is plausible to assume that HIV infection may ameliorate the angiogenic imbalance in preeclampsia.

Keywords

Angiogenesis Preeclampsia Soluble fms-like tyrosine kinase 1 Vascular endothelial growth factor Placental growth factor HIV 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Sayuri Padayachee
    • 1
    Email author
  • Jagidesa Moodley
    • 2
  • Thajasvarie Naicker
    • 1
  1. 1.Optics and Imaging Centre, Doris Duke Medical Research Institute, Nelson R. Mandela School of MedicineUniversity of KwaZulu-NatalDurbanSouth Africa
  2. 2.Women’s Health and HIV Research Group, Department of Obstetrics and Gynecology, Nelson R. Mandela School of MedicineUniversity of KwaZulu-NatalDurbanSouth Africa

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