Effect of L-Citrulline Supplementation on Blood Pressure: a Systematic Review and Meta-Analysis of Clinical Trials
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Purpose of Review
Several interventional studies assessed the impact of dietary supplements on blood pressure. The aim of the present systematic review and meta-analysis was to determine the efficacy of L-citrulline supplementation on blood pressure.
Pubmed, Scopus, Google Scholar, and ISI Web of Science were comprehensively searched until May 2018 to assess whether L-citrulline reduces blood pressure. Human clinical trials which reported the effect of L-citrulline supplementation on aortic and brachial blood pressure were included. Characteristics of studies and potential sources of heterogeneity were tabulated. A subgroup analysis was performed to attenuate observed inter-study heterogeneity. A total of five interventions were found for meta-analysis. The impact of L-citrulline on brachial systolic (change 0.28 mmHg; 95% CI − 2.87, 2.31 mmHg) and diastolic (change − 1.56 mmHg; 95% CI − 4.32, 1.20 mmHg) blood pressure was not significant. Also, there was no changes in aortic systolic (change 0.22 mmHg; 95% CI − 4.81, 4.38 mmHg) and diastolic (change 0.26 mmHg; 95% CI − 2.27, 2.80 mmHg) blood pressure after L-citrulline supplementation. Participants’ body weight status was a source of observed heterogeneity.
The present systematic review and meta-analysis suggests that L-citrulline supplementation had no beneficial effect on blood pressure.
KeywordsL-citrulline Blood pressure Systematic review Meta-analysis
Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran, supported the present study.
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflicts of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
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