Catheter-Based Renal Denervation for Hypertension
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Purpose of Review
This review was undertaken to update readers on the field of therapeutic renal denervation for hypertension during the 2016 through 2018 period.
After the failure of Symplicity HTN-3 to meet its top line objective, intense scrutiny revealed several possible concerns addressed by the newer investigations into the area of renal denervation. These included better device technology, more intense subject monitoring for off-protocol antihypertensive drug usage, and deeper penetration into the renal vasculature by the interventionist.
Whether untreated by medication for hypertension or on antihypertensive medication, renal denervation shows a clear, though moderate, blood pressure reduction. The failure of roughly one out of three patients with hypertension to respond to denervation procedures argues that there is room for improvement in choosing the optimal patient for this approach to hypertension management.
KeywordsRenal denervation Hypertension Radiofrequency ablation Ultrasound ablation Alcohol ablation
Compliance with Ethical Standards
Conflict of Interest
Dr. Townsend reports personal fees from Medtronic and Rox Medical, outside the submitted work. Dr. Sobotka is Executive Consultant to Rox Medical.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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