Novel Medical Treatments for Hypertension and Related Comorbidities

  • Jared DavisEmail author
  • Suzanne Oparil
Novel Treatments for Hypertension (T Unger, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Novel Treatments for Hypertension


Purpose of Review

The purpose of this review is to summarize the most recent data available on advances in development of novel medical treatments for hypertension and related comorbidities.

Recent Findings

Approximately half of all hypertensive patients have not achieved goal blood pressure with current available antihypertensive medications. Recent landmark studies and new hypertension guidelines have called for stricter blood pressure control, creating a need for better strategies for lowering blood pressure. This has led to a shift in focus, in recent years, to the development of combination pills as a means of achieving improved blood pressure control by increasing adherence to prescribed medications along with further research and development of promising novel drugs based on discovery of new molecular targets such as the counter-regulatory renin-angiotensin system.


Fixed-dose combination pills and novel treatments based on recently discovered pathogenic mechanisms of hypertension that have demonstrated promising results as treatments for hypertension and related comorbidities will be discussed in this review.


Hypertension Blood pressure Novel treatments Medications 


Compliance with Ethical Standards

Conflict of Interest

The authors declare no conflicts of interest relevant to this manuscript.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of MedicineUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.UAB Vascular Biology and Hypertension Program, Division of Cardiovascular DiseaseUniversity of Alabama at BirminghamBirminghamUSA

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