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Current Hypertension Reports

, 16:416 | Cite as

AT2 Receptor and Tissue Injury: Therapeutic Implications

  • Pawel Namsolleck
  • Chiara Recarti
  • Sébastien Foulquier
  • Ulrike Muscha Steckelings
  • Thomas UngerEmail author
Mediators, Mechanisms, and Pathways in Tissue Injury (T Fujita, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Mediators, Mechanisms, and Pathways in Tissue Injury

Abstract

The renin-angiotensin system (RAS) plays an important role in the initiation and progression of tissue injuries in the cardiovascular and nervous systems. The detrimental actions of the AT1 receptor (AT1R) in hypertension and vascular injury, myocardial infarction and brain ischemia are well established. In the past twenty years, protective actions of the RAS, not only in the cardiovascular, but also in the nervous system, have been demonstrated. The so-called protective arm of the RAS includes AT2-receptors and Mas receptors (AT2R and MasR) and is characterized by effects different from and often opposing those of the AT1R. These include anti-inflammation, anti-fibrosis, anti-apoptosis and neuroregeneration that can counterbalance pathological processes and enable recovery from disease. The recent development of novel, small-molecule AT2R agonists offers a therapeutic potential in humans with a variety of clinical indications.

Keywords

Renin-angiotensin system AT2 receptor Angiotensin II CGP42112 PD123319 Signaling Tissue injury Inflammation Fibrosis Apoptosis Growth promotion/inhibition Cardioprotection Vascular protection Neuroprotection Neuroregeneration Myocardial infarction Aortic aneurysm Atherosclerosis Hypertension Stroke Spinal cord injury 

Notes

Compliance with Ethics Guidelines

Conflict of Interest

Pawel Namsolleck, Chiara Recarti, Sébastien Foulquier, and Thomas Unger declare that they have no conflict of interest.

Ulrike Muscha Steckelings has received modest research support (short term fellowship; free supply with drug) from Vicore Pharma.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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© The Author(s) 2014

Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

Authors and Affiliations

  • Pawel Namsolleck
    • 1
  • Chiara Recarti
    • 1
  • Sébastien Foulquier
    • 1
  • Ulrike Muscha Steckelings
    • 2
  • Thomas Unger
    • 1
    Email author
  1. 1.CARIM - School for Cardiovascular DiseasesMaastricht UniversityMaastrichtThe Netherlands
  2. 2.Institute of Molecular Medicine, Department of Cardiovascular and Renal PhysiologyUniversity of Southern DenmarkOdenseDenmark

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