Should We Screen High-Risk Populations for NAFLD?

  • Cyrielle CaussyEmail author
Fatty Liver Disease (V Ajmera, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Fatty Liver Disease


Purpose of review

Nonalcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease worldwide and yet remains largely underdiagnosed. However, whether a systematic screening in high-risk population for NAFLD should be performed remains debated.

Recent findings

Over the past decade, a better knowledge of the natural history and epidemiology of NAFLD has identified high-risk population for NAFLD including obese and type 2 diabetes patients. Moreover, the presence of advanced fibrosis has been identified as the major determinant of overall and liver-related mortality. Moreover, several non-invasive biomarkers have been developed for the screening of advanced fibrosis while therapeutic clinical trials are intensive field of research.


Screening for advanced fibrosis in high-risk population for NAFLD should be performed as it would benefit to the patients. However further studies are needed to determine the optimal strategy and cost-effectiveness of such screening.


Obesity Nonalcoholic fatty liver disease Type 2 diabetes Fibrosis Cirrhosis Biomarkers 


Compliance with Ethical Standards

Conflict of Interest

Cyrielle Caussy is a consultant for Gilead, NovoNordisk, Liponexus, AstraZeneca.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Univ Lyon, CarMen Laboratory, INSERM, INRA, INSA LyonUniversité Claude Bernard Lyon 1Pierre-BéniteFrance
  2. 2.Hospices Civils de Lyon, Département Endocrinologie, Diabète et NutritionHôpital Lyon SudPierre-BéniteFrance

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