Current Hepatology Reports

, Volume 18, Issue 3, pp 310–315 | Cite as

Chronic Hepatitis B in US Veterans

  • Patrik Garren
  • Marina SerperEmail author
Hepatitis B (JK Lim, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Hepatitis B


Purpose of Review

This review summarizes recent data on chronic hepatitis B virus (HBV) epidemiology, issues in special populations undergoing immunosuppressive and hepatitis C virus (HCV) direct-acting antiviral (DAA) therapy, and describes care delivery, adherence to guideline-recommended care, and barriers to access to care and high-quality care for chronic HBV.

Recent Findings

Chronic HBV is present in up to 1% of veterans and is more than in the general US population. HBV is associated with more advanced liver disease in HCV, HIV, and delta hepatitis co-infection. Recent data on HBV reactivation show a substantial risk of reactivation with anti-CD20 antibodies, no documented cases of reactivation with anti-tumor necrosis factor (anti-TNF) therapy, and a low risk of reactivation with HCV DAA therapy. Adherence to guideline-recommended care for HBV is suboptimal for many quality indicators.


Important studies in HBV epidemiology, long-term outcomes, and care delivery practices have been conducted in the VA. Future studies should prospectively investigate how to improve guideline-recommended care for HBV.


Hepatitis delta Hepatocellular carcinoma Cirrhosis Hepatitis B epidemiology Care quality Hepatitis B reactivation 


Compliance with Ethical Standards

Conflict of Interest

Patrik Garren declares no potential conflicts of interest. Marina Serper reports consulting fees from BioVie, Inc. outside the submitted work.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Division of GastroenterologyUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaUSA
  2. 2.Corporal Michael J. Crescenz VA Medical CenterPhiladelphiaUSA
  3. 3.Leonard Davis Institute of Health EconomicsPhiladelphiaUSA

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