Current Hepatology Reports

, Volume 18, Issue 3, pp 274–279 | Cite as

Global Epidemiology of Drug-Induced Liver Injury (DILI)

  • Einar S. BjörnssonEmail author
Drug-Induced Liver Injury (P Hayashi, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Drug-Induced Liver Injury


Purpose of Review

Drug-induced liver injury (DILI) is not an uncommon liver disease in many parts of the world. DILI is one of the most common causes of acute liver failure in most countries. The current review summarizes the global epidemiology of DILI.

Recent Findings

The number need to harm in terms of DILI due to amoxicillin-clavulanate was approximately 1 out 2300, but was higher for azathioprine (1 out of 133) and infliximab (1 out of 148). A retrospective Chinese study showed the highest rate of DILI in hospitalized patients with an incidence of approximately 24 patients per 100,000 annually with a more favorable prognosis in the DILI cohort than previously reported from Europe, the USA, and Asia.


Although large DILI registries from Europe and the USA have collected much data, more prospective studies with continual enrollment are needed particularly as new therapies such as immune modulatory and oncological medications with longer half-lives and latencies come to market.


DILI Hepatotoxicity Epidemiology Incidence Prognosis Global 


Compliance with Ethical Standards

Conflict of Interest

Einar S. Björnsson declares no potential conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by the author.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Authors and Affiliations

  1. 1.Faculty of Medicine, University of IcelandThe National University Hospital of IcelandReykjavikIceland
  2. 2.Department of Internal Medicine and Division of Gastroenterology and HepatologyThe National University Hospital of IcelandReykjavikIceland
  3. 3.Faculty of MedicineThe National University Hospital of IcelandReykjavikIceland

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