Venetoclax for the Treatment of Chronic Lymphocytic Leukemia
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Purpose of this Review
This review summarizes the role of BCL-2 in the pathogenesis of CLL, and the clinical data evaluating safety and efficacy of venetoclax, in treatment of patients with CLL, in the context of other available targeted agents.
Venetoclax, alone or in combination with other targeted agents results in high rate of durable responses and undetectable measurable residual disease. Venetoclax maintains activity across all clinical and biologic subgroups, including those with high risk disease, including CLL with chromosome 17p deletion. TLS risk can be mitigated with risk stratification and five-week administration ramp-up schedule.
Venetoclax, a novel, orally bioavailable inhibitor of BCL-2 has demonstrated substantial clinical activity in the treatment of CLL. In combination with other targeted agents it can induce high disease response rates and potentially lead to MRD-negative durable remissions.
KeywordsCLL Venetoclax BCL-2
Bruton’s tyrosine kinase
Chronic lymphocytic leukemia
Progression free survival
Relapsed or refractory
Independent review committee
Minimal residual disease
Immunoglobulin heavy chain variable region
Tumor lysis syndrome
Compliance with Ethical Standards
Conflict of Interest
Herbert Eradat declares that he has no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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