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Venetoclax for the Treatment of Chronic Lymphocytic Leukemia

  • Herbert EradatEmail author
Chronic Lymphocytic Leukemias (N Jain, Section Editor)
  • 110 Downloads
Part of the following topical collections:
  1. Topical Collection on Chronic Lymphocytic Leukemias

Abstract

Purpose of this Review

This review summarizes the role of BCL-2 in the pathogenesis of CLL, and the clinical data evaluating safety and efficacy of venetoclax, in treatment of patients with CLL, in the context of other available targeted agents.

Recent Findings

Venetoclax, alone or in combination with other targeted agents results in high rate of durable responses and undetectable measurable residual disease. Venetoclax maintains activity across all clinical and biologic subgroups, including those with high risk disease, including CLL with chromosome 17p deletion. TLS risk can be mitigated with risk stratification and five-week administration ramp-up schedule.

Summary

Venetoclax, a novel, orally bioavailable inhibitor of BCL-2 has demonstrated substantial clinical activity in the treatment of CLL. In combination with other targeted agents it can induce high disease response rates and potentially lead to MRD-negative durable remissions.

Keywords

CLL Venetoclax BCL-2 

Abbreviations

BTK

Bruton’s tyrosine kinase

CLL

Chronic lymphocytic leukemia

OS

Overall survival

PR

Partial remission

PD

Progressive disease

PFS

Progression free survival

R/R

Relapsed or refractory

IRC

Independent review committee

MRD

Minimal residual disease

PI3K

Phosphatidylinositol-3 kinase

IgVH

Immunoglobulin heavy chain variable region

TLS

Tumor lysis syndrome

Notes

Compliance with Ethical Standards

Conflict of Interest

Herbert Eradat declares that he has no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.David Geffen School of Medicine at UCLAUniversity of California, Los AngelesLos AngelesUSA

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