Current Hematologic Malignancy Reports

, Volume 14, Issue 3, pp 145–153 | Cite as

Key Role of Inflammation in Myeloproliferative Neoplasms: Instigator of Disease Initiation, Progression. and Symptoms

  • Laura F. Mendez Luque
  • Amanda L. Blackmon
  • Gajalakshmi Ramanathan
  • Angela G. FleischmanEmail author
Myeloproliferative Neoplasms (B Stein, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Myeloproliferative Neoplasms


Purpose of Review

Chronic inflammation is a characteristic feature of myeloproliferative neoplasm (MPN) and impacts many aspects of the disease including initiation, progression, and symptomatology.

Recent Findings

The chronic inflammatory state of MPN results from disruption of immune signaling pathways leading to overproduction of inflammatory cytokines by both the neoplastic clones and bystander immune cells. This chronic inflammation may allow for the neoplastic clone to gain a selective advantage. The symptomatic burden felt by MPN patients may be a result of the chronic inflammation associated with MPN, as several cytokines have been linked with different symptoms. Pharmacologic as well as nonpharmacologic treatments of the inflammatory component of this disease may lead to decreased symptomatic burden, prevention of disease progression, and improvement in overall disease trajectory.


Inflammation plays a key role in the pathogenesis of MPN and represents an important therapeutic target.


Myeloproliferative neoplasm JAK/STAT signaling Inflammation in cancer Diet in cancer Lifestyle in cancer Inflammatory cytokines Fatigue Quality of life Nonpharmacological approaches 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: •• Of major importance

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Laura F. Mendez Luque
    • 1
  • Amanda L. Blackmon
    • 2
  • Gajalakshmi Ramanathan
    • 2
  • Angela G. Fleischman
    • 1
    • 2
    • 3
    Email author
  1. 1.Department of Biological ChemistryUniversity of California IrvineIrvineUSA
  2. 2.Division of Hematology/Oncology, Department of MedicineUniversity of California IrvineIrvineUSA
  3. 3.Chao Family Comprehensive Cancer CenterUniversity of California IrvineIrvineUSA

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