Current Heart Failure Reports

, Volume 15, Issue 5, pp 315–321 | Cite as

Non-response to Cardiac Resynchronization Therapy

  • Syed Yaseen Naqvi
  • Anas Jawaid
  • Ilan Goldenberg
  • Valentina KutyifaEmail author
Devices (C. Veltmann, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Devices


Purpose of Review

Cardiac resynchronization therapy (CRT) is an effective treatment option for therapy-refractory mild to severe heart failure (HF) patients with reduced ejection fraction and left ventricular (LV) conduction delay. Multiple clinical trials have shown that CRT improves cardiac function and overall quality of life, as well as reduces HF hospitalizations, health care costs, and mortality.

Recent Findings

Despite its effectiveness, the “non-response” rate to CRT is around 30%, remaining a major challenge that faces electrophysiologists and researchers. It has been recently suggested that the etiology of CRT non-response is multifactorial, and it requires a multifaceted approach to address it.


In this focused review, we will summarize the definitions of CRT non-response, identify key factors for CRT non-response, and offer a simplified framework to address CRT non-response with the main goal of improving CRT outcomes.


Cardiac resynchronization therapy CRT Heart failure Cardiac function CRT response CRT non-response 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Syed Yaseen Naqvi
    • 1
  • Anas Jawaid
    • 1
  • Ilan Goldenberg
    • 1
  • Valentina Kutyifa
    • 1
    Email author
  1. 1.Heart Research Follow-Up Program, Cardiology DivisionUniversity of Rochester Medical CenterRochesterUSA

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