Increased Use of Emulsifiers in Processed Foods and the Links to Obesity
Purpose of Review
The purpose of this review is to discuss the implications of the increased prevalence of emulsifiers in processed foods in daily consumption, the links to obesity both in mice and in vitro studies, and how those findings correlate with humans.
There is rising interest in understanding the contributors to the obesity epidemic. One potential component recently studied has been the consumption of processed foods causing inflammatory changes leading to metabolic syndrome. This phenomenon has been shown in several mice and in vitro studies with changes in microbiome composition, elevated fasting blood glucose, hyperphagia, increased weight gain and adiposity, hepatic steatosis increased inflammatory markers, and a correlation with increased incidence of colorectal cancer.
Emulsifiers are found in most foods consumed in the US population, which has increased over the years. This review focuses on understanding the initial approved safe levels of emulsifier consumption, the preceding increased use in foods with higher daily consumption than was previously tested, measuring these levels in animal models, and the positive association with obesity and metabolic syndrome. Future research will require prospectively studying emulsifier consumption more accurately along with the associated respective changes in the microbiome to determine the relationship to obesity.
KeywordsEmulsifier Obesity Metabolic syndrome Nutrition Gut microbiome Processed foods
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
- 1.Centers for Disease Control and Prevention: Overweight &Obesity. Available from: https://www.cdc.gov/obesity/data/adult.html. Assessed 27 Mar 2019.
- 8.• Halmos EP, Mack A, Gibson PR. Review article: emulsifiers in the food supply and implications for gastrointestinal disease. Aliment Pharmacol Ther. 2019;49:41–50 This article describes the different types of emulsifiers and how they may be implicated in gastrointestinal diseases. CrossRefGoogle Scholar
- 9.World Health Organization: Food additives. Available from: https://www.who.int/news-room/fact-sheets/detail/food-additives. Accessed 4 Feb 2019
- 10.U.S. Food & Drug Administration: Food Additives & Ingredients. Available from: https://www.fda.gov/food/ingredientspackaginglabeling/foodadditivesingredients/ucm094211.htm#foodadd. Accessed 4 Feb 2019.
- 15.World Health Organization Technical Report Series. 2017:1000:1-162. Evaluation of certain food additives.Google Scholar
- 17.Kindy K. Food additives on the rise as FDA scrutiny wanes. The Washington Post. August 17, 2017. Available from: https://www.washingtonpost.com/national/food-additives-on-the-rise-as-fda-scrutiny-wanes/2014/08/17/828e9bf8-1cb2-11e4-ab7b-696c295ddfd1_story.html?noredirect=on&utm_term=.4f6c055a99bb. Assessed 4 Feb 2019.
- 27.•• Hall K, Ayuketah A, Brychta R, Cai H, Cassimatis T, Chen K, et al. Ultra-processed diets cause excess calorie intake and weight gain: an inpatient randomized controlled trial of ad libitum food intake. Cell Metab. 2019;30:1–11 This is a randomized control trial comparing the metabolic changes associated with ultra-processed vs minimally processed diets. CrossRefGoogle Scholar