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Current Diabetes Reports

, 18:125 | Cite as

Diabetes and HIV

  • Emile Camille Noubissi
  • Jean-Claude Katte
  • Eugene Sobngwi
Other Forms of Diabetes and Its Complications (JJ Nolan and H Thabit, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Other Forms of Diabetes and Its Complications

Abstract

Purpose of Review

This review seeks to address the epidemiology and pathophysiological basis of the interaction between HIV infection and diabetes and the implication for treatment. Its importance stems from the current context of the growing burden of both conditions and the possible mechanisms of interactions that may exist but not yet sufficiently examined.

Recent Findings

HIV infection is associated with increased risk of insulin resistance, and ART is associated with metabolic derangement and the occurrence of type 2 diabetes. The increasing survival among people with HIV infection in developing countries is paralleled by a growing burden of chronic non-communicable diseases (NCDs) especially cardiovascular diseases and diabetes mellitus. The prevalence of diabetes mellitus is higher in HIV-positive persons compared to the general population, and especially those with associated hepatitis C virus (HCV) co-infection. Antiretroviral therapy (ART) during chronic HIV infection is the most incriminated risk factor for the development of diabetes mellitus through diverse mechanisms depending on the ART leading to insulin resistance and increased inflammatory status.

Summary

A staggering 629 million of people 20–79 years are projected to have diabetes by 2045 while the world will soon enter the fourth decade of the HIV infection. Classical risk factors for diabetes such as physical inactivity and unhealthy diet may not solely explain the current trends, suggesting the role of novel risk factors including infections/inflammation. HIV and its treatment have been identified as potential contributors. Co-infections frequently observed during HIV infection also significantly influence both the epidemiological and pathophysiological of the link between HIV and diabetes. Although the relative contribution of each risk factor has not yet been quantified, several lines of evidence suggest that ART is a major contributor to hyperglycemia in HIV infection. ARTs have also led to an increase in metabolic dysfunction, including insulin resistance syndromes, dyslipidemia, and lipodystrophy. The association between ARTs and the risk of developing diabetes therefore calls for a careful choice of medication and evaluation of the risk of developing diabetes.

Keywords

HIV infection Diabetes Anti-retroviral treatment Complications 

Notes

Compliance with Ethical Standards

Conflict of Interest

Emile Camille Noubissi, Jean-Claude Katte, and Eugene Sobngwi declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Emile Camille Noubissi
    • 1
  • Jean-Claude Katte
    • 2
  • Eugene Sobngwi
    • 3
    • 4
  1. 1.Department of Biochemistry, Faculty of Medicine and Biomedical SciencesUniversity of Yaoundé 1YaoundéCameroon
  2. 2.Department of Public Health, Faculty of Medicine and Biomedical SciencesUniversity of Yaoundé 1YaoundéCameroon
  3. 3.National Obesity Center and Endocrine and Metabolic Diseases UnitYaoundé Central HospitalYaoundéCameroon
  4. 4.Department of Internal Medicine and Specialities, Faculty of Medicine and Biomedical SciencesUniversity of Yaoundé 1YaoundéCameroon

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