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Precision Medicine Approaches to Diabetic Kidney Disease: Tissue as an Issue

  • Microvascular Complications—Nephropathy (M Afkarian, Section Editor)
  • Published:
Current Diabetes Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Precision medicine approaches, that tailor medications to specific individuals has made paradigm-shifting improvements for patients with certain cancer types.

Recent Findings

Such approaches, however, have not been implemented for patients with diabetic kidney disease. Precision medicine could offer new avenues for novel diagnostic, prognostic and targeted therapeutics development. Genetic studies associated with multiscalar omics datasets from tissue and cell types of interest of well-characterized cohorts are needed to change the current paradigm.

Summary

In this review, we will discuss precision medicine approaches that the nephrology community can take to analyze tissue samples to develop new therapeutics for patients with diabetic kidney disease.

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Author information

Author notes

  1. Caroline Gluck and Yi-An Ko Contributed equally

Authors and Affiliations

  1. Renal-Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 415 Curie Blvd, 415 Clinical Research Building, Philadelphia, PA, 19104, USA

    Caroline Gluck, Yi-An Ko & Katalin Susztak

  2. Division of Nephrology, The Children’s Hospital of Philadelphia, Philadelphia, PA, 19104, USA

    Caroline Gluck

  3. Department of Genetics Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Yi-An Ko & Katalin Susztak

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  1. Caroline Gluck
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  3. Katalin Susztak
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Correspondence to Katalin Susztak.

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Conflict of Interest

Caroline Gluck and Yi-An Ko declare that they have no conflict of interest.

Katalin Susztak reports grants from Biogen, ONO Pharma, Boehringer Ingelheim, Regeneron, GSK, Celgene, NIH, and JDRF.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Microvascular Complications—Nephropathy

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Gluck, C., Ko, YA. & Susztak, K. Precision Medicine Approaches to Diabetic Kidney Disease: Tissue as an Issue. Curr Diab Rep 17, 30 (2017). https://doi.org/10.1007/s11892-017-0854-7

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  • DOI: https://doi.org/10.1007/s11892-017-0854-7

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