Nutrigenetics of Blood Cholesterol Concentrations: Towards Personalized Nutrition

  • Itzel Vazquez-Vidal
  • Charles Desmarchelier
  • Peter J. H. JonesEmail author
Public Health Policy (E Klodas, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Public Health Policy


Purpose of the Review

To summarize achievements made in the field of nutrigenetics to personalized nutrition. Moreover, the limitations and challenges observed to enable clinical utilization are discussed.

Recent Findings

Currently, with the availability of low-cost genetic testing and new bioinformatics tools, significant developments have occurred to allow issues inherent to the highly complex nature of genetic data to be tackled. Moreover, new statistical methods have uncovered combinatory patterns of SNPs that collectively explain the high interindividual variability in response to dietary interventions. Yet, the application of these results to personalized dietary recommendations is not straightforward.


Data from gene-nutrient interaction studies have provided evidence to understand the inter-individual variation differences in blood cholesterol responses. A need exists for guidelines and regulations in order to apply nutrigenetics to personalized nutrition. Moreover, a multisystem approach including genetics, microbiome and environment is needed to achieve possible practical applications.


Gene-nutrient interactions Lipid Cardiovascular disease Single nucleotide polymorphisms Genetic variant 



The authors thank Stephanie Jew for her helpful input and for her scientific writing assistance in the development of this article.

Compliance with Ethical Standards

Conflict of Interest

Itzel Vazquez-Vidal and Charles Desmarchelier declare that they have no conflict of interest. Peter J. H Jones has received research grants from Nutritional Fundamentals for Health Inc., Mitacs, and the International Life Sciences Institute. He also owns stock in Nutritional Fundamentals for Health Inc.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Itzel Vazquez-Vidal
    • 1
  • Charles Desmarchelier
    • 2
  • Peter J. H. Jones
    • 1
    • 3
    Email author
  1. 1.Richardson Centre for Functional Foods and NutraceuticalsUniversity of ManitobaWinnipegCanada
  2. 2.Aix Marseille Univ, INRA, INSERM, C2VNMarseilleFrance
  3. 3.Department of Food and Human Nutritional SciencesUniversity of ManitobaWinnipegCanada

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