Recent Non-neurogenic Overactive Bladder Trials

  • Luiz Gustavo Oliveira BritoEmail author
  • Luis Guilherme Teixeira dos Santos
Overactive Bladder (U Lee and S Adelstein, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Overactive Bladder
  2. Topical Collection on Overactive Bladder


Purpose of Review

We sought to address the most important trials regarding overactive bladder (OAB) syndrome published in the past 5 years regarding pharmacological treatment and minimally invasive procedures (botulinum toxin A, percutaneous tibial nerve stimulation, and sacral neuromodulation).

Recent Findings

Most of the randomized controlled trials related to OAB are studying anticholinergics and/or beta-adrenergics versus each other or to a placebo-comparator group. Studies have shown stability of using mirabegron and that combination therapy (anticholinergics plus beta-adrenoceptors) seems a good choice for patients with OAB. Percutaneous tibial nerve stimulation needs further studies with comparators to confirm its role. Regarding intra-vesical botulinic toxin or sacral neuromodulation for OAB, both options present good percentages of patient improvement, with no clinically significant difference between them to this moment.


Despite a growing number of high-quality randomized trials on OAB, further studies are needed comparing different lines of treatment for this disease.


Overactive bladder Randomized controlled trials Treatment Review 


Compliance with Ethical Standards

Conflict of Interest

The authors declare no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Luiz Gustavo Oliveira Brito
    • 1
    Email author
  • Luis Guilherme Teixeira dos Santos
    • 2
  1. 1.Department of Obstetrics and Gynecology, School of Medical SciencesUniversity of CampinasCampinasBrazil
  2. 2.Hospital Universitario Antonio PedroFluminense Federal UniversityNiteróiBrazil

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