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Weight Loss and Overactive Bladder

  • Christopher Caputo
  • Alexander Uhr
  • Alana Murphy
Overactive Bladder and Lower Urinary Tract Symptoms (U Lee and S Adelstein, Section Editors)
  • 8 Downloads
Part of the following topical collections:
  1. Topical Collection on Overactive Bladder and Lower Urinary Tract Symptoms

Abstract

Purpose of Review

We sought to explore the relationship between obesity and overactive bladder (OAB) and to review the available literature that supports weight loss as a means to alter OAB severity and bother.

Recent Findings

Over the past 15 years, several population-based human studies and animal models have identified obesity as a risk factor for the development of OAB. The bariatric surgery literature demonstrates that substantial weight loss following some form of gastric bypass can lead to at least subjective improvement in OAB symptoms. Ongoing research seeks to further elucidate the role of anti-inflammatory agents, anti-oxidants, and β3-receptor agonists in obesity-associated OAB.

Summary

The currently available literature has identified obesity as a risk factor for the development OAB. Data taken from the bariatric surgery literature indicates that surgical weight loss can lead to a significant improvement in OAB severity and bother. Future studies will determine if less dramatic weight changes can lead to significant and sustained changes in OAB parameters. Based on the available literature, clinicians should start to counsel their obese patients with OAB that weight loss can help improve their OAB severity and bother.

Keywords

Overactive bladder Obesity Metabolic syndrome Urinary urgency 

Abbreviations

OAB

Overactive bladder

UUI

Urgency urinary incontinence

BMI

Basic metabolic index

IPSS

International Prostate Symptom Score

OABSS

Overactive Bladder Symptom Score

SUI

Stress urinary incontinence

MUI

Mixed urinary incontinence

OABq SF

Overactive Bladder Questionnaire Short Form

BAT

Brown adipose tissue

PPIUS

Patients’ Perception of Intensity of Urgency Scale

IL

Interleukin

TNF

Tumor necrosis factor

PDE

Phosphodiesterase

Notes

Compliance With Ethical Standards

Conflict of Interest

C Caputo: none

A Uhr: none

A Murphy: none

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Christopher Caputo
    • 1
  • Alexander Uhr
    • 1
  • Alana Murphy
    • 1
  1. 1.Department of UrologyThomas Jefferson University HospitalPhiladelphiaUSA

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