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Non-alcoholic Fatty Liver Disease and Its Links with Inflammation and Atherosclerosis


Purpose of Review

We summarize best data of the association between non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD).

Recent Findings

NAFLD has been linked with insulin resistance, obesity, and metabolic syndrome, conditions known to be associated with CVD and subclinical atherosclerosis. The rising evidence of the association between NAFLD and subclinical CVD may suggest that NAFLD is not only a marker but also may be actively involved in pathogenesis of CVD.


It is an overview of previous studies assessing relationships between NAFLD and markers of cardiovascular disease, as the presence of coronary artery calcification, increased arterial stiffness, and elevated carotid media thickness, in order to better understand the interplay between these conditions.

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Fig. 1



Non-alcoholic fatty liver disease


Metabolic syndrome


Bone mineral density


Non-alcoholic steatohepatitis


Carotid wall intimal medial thickness




Tumor necrosis factor α


Coronary artery heart disease


Apoprotein B


Free fatty acid


C-reactive protein


Alanine aminotransferase


Aspartate aminotransferase


Cardiovascular disease


Low density lipoprotein


Very low density lipoprotein


High density lipoprotein


Flow mediated dilation


Odds ratio


Confidence interval


P value


Coronary artery calcification


Carotid-femoral pulse wave velocity


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Author information

Priscila Pollo-Flores supervised the study. Débora Vieira-Soares did critical review of the manuscript. Gabriela Muller-Machado drafted and did critical revision of manuscript. Luan Abdallah, Ricardo Cardoso de Matos and Yves Pacheco Dias March e Souza drafted and wrote the manuscript.

Correspondence to Priscila Pollo-Flores.

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Abdallah, L.R., de Matos, R.C., e Souza, Y.P.D.M. et al. Non-alcoholic Fatty Liver Disease and Its Links with Inflammation and Atherosclerosis. Curr Atheroscler Rep 22, 7 (2020). https://doi.org/10.1007/s11883-020-0820-8

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  • Non-alcoholic fatty liver disease
  • Steatohepatitis
  • Inflammation
  • Cardiovascular risks
  • Atherosclerosis
  • Aortic stiffness
  • Carotid media thickness
  • Coronary artery calcification