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Effect of Aerobic Exercise on Peak Oxygen Consumption, VE/VCO2 Slope, and Health-Related Quality of Life in Patients with Heart Failure with Preserved Left Ventricular Ejection Fraction: a Systematic Review and Meta-Analysis

  • Mansueto Gomes-NetoEmail author
  • André Rodrigues Durães
  • Lino Sergio Rocha Conceição
  • Leonardo Roever
  • Tong Liu
  • Gary Tse
  • Giuseppe Biondi-Zoccai
  • Ana Lucia Barbosa Goes
  • Iura Gonzalez Nogueira Alves
  • Øyvind Ellingsen
  • Vitor Oliveira Carvalho
Evidence-Based Medicine, Clinical Trials and Their Interpretations (L. Roever, Section Editor)
  • 100 Downloads
Part of the following topical collections:
  1. Topical Collection on Evidence-Based Medicine, Clinical Trials and Their Interpretations

Abstract

Purpose of Review

The aim of this study was to determine the effects of aerobic exercise on peak oxygen uptake (peak VO2), minute ventilation/carbon dioxide production (VE/VCO2 slope), and health-related quality of life (HRQoL) among patients with heart failure (HF) and preserved ejection fraction (HFpEF).

Recent Findings

We conducted a Cochrane Library, MEDLINE/PubMed, Physiotherapy Evidence Database, and SciELO search (from 1985 to May 2019) for randomized controlled trials that evaluated the effects of aerobic exercise in HFpEF patients. We calculated the mean differences (MD) and 95% confidence interval (CI). Ten intervention studies were included providing a total of 399 patients. Compared with control, aerobic exercise resulted in improvement in peak VO2 MD 1.9 mL kg−1 min−1 (95% CI 1.3 to 2.5; N = 314) and HRQoL measured by Minnesota Living with Heart Failure MD 5.4 (95% CI − 10.5 to − 0.2; N = 256). No significant difference in VE/VCO2 slope was found between participants in the aerobic exercise group and the control group. The quality of evidence for peak VO2 and HRQoL was assessed as being moderate.

Summary

Aerobic exercise moderately improves peak VO2 and HRQoL and should be considered a strategy of rehabilitation of HFpEF individuals.

Keywords

Aerobic exercise Heart failure Left ventricular ejection fraction 

Notes

Compliance with Ethical Standards

Conflict of Interest

Mansueto Gomes Neto, André Rodrigues Durães, Lino Sergio Rocha Conceição, Leonardo Roever, Tong Liu7 Gary Tse, Giuseppe Biondi-Zoccai, Ana Lucia Barbosa Goes, Lura Gonzalez Nogueira Alves, Øyvind Ellingsen, and Vitor Oliveira Carvalho declare they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Supplementary material

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Mansueto Gomes-Neto
    • 1
    • 2
    • 3
    • 4
    Email author
  • André Rodrigues Durães
    • 2
  • Lino Sergio Rocha Conceição
    • 4
    • 12
  • Leonardo Roever
    • 5
  • Tong Liu
    • 6
    • 7
  • Gary Tse
    • 8
  • Giuseppe Biondi-Zoccai
    • 9
  • Ana Lucia Barbosa Goes
    • 1
    • 3
  • Iura Gonzalez Nogueira Alves
    • 3
  • Øyvind Ellingsen
    • 10
    • 11
  • Vitor Oliveira Carvalho
    • 4
    • 12
  1. 1.Physical Therapy Department, Instituto de Ciências da SaúdeFederal University of Bahia – UFBASalvadorBrazil
  2. 2.Programa de Pós-Graduação em Medicina e SaúdeUFBASalvadorBrazil
  3. 3.Physiotherapy Research GroupUFBASalvadorBrazil
  4. 4.The GREAT Group (GRupo de Estudos em ATividade física)São PauloBrazil
  5. 5.Department of Clinical ResearchFederal University of UberlândiaUberlândiaBrazil
  6. 6.Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of CardiologyThe Second Hospital of Tianjin Medical UniversityTianjinChina
  7. 7.Shenzhen Research InstituteThe Chinese University of Hong KongHong KongChina
  8. 8.Department of Medico-Surgical Sciences and BiotechnologiesSapienza University of RomeLatinaItaly
  9. 9.Mediterranea CardiocentroNaplesItaly
  10. 10.K.G. Jebsen Center for Exercise in Medicine, Department of Circulation and Medical Imaging, Faculty of Medicine and Health SciencesNorwegian University of Science and TechnologyTrondheimNorway
  11. 11.Department of Cardiology, Trondheim University HospitalSt. Olavs HospitalTrondheimNorway
  12. 12.Physical Therapy DepartmentFederal University of Sergipe – UFSAracajuBrazil

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