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The Effects of Obesity in Asthma

  • Arjun Mohan
  • Jon Grace
  • Bonnie R. Wang
  • Njira LugogoEmail author
Asthma (V Ortega, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Asthma

Abstract

Purpose of Review

Rising costs and increasing morbidity makes the identification and treatment of high-risk asthma phenotypes important. In this review, we outline the complex relationship between obesity and asthma.

Recent Findings

Studies have confirmed a bi-directional relationship between obesity and asthma. Pathophysiological factors implicated include genetic risk, the effect of diet and microbiome, and obesity-related cytokines. There have been robust, albeit derived, efforts to phenotype this group with distinct clinical presentations based on age of onset of asthma. Unfortunately, the poor performance of biomarkers and traditional lung function testing has impeded diagnosis, phenotyping, and management of the obese asthma patient. There is also a lack of targeted interventions with weight loss showing some benefits.

Summary

Obesity increases the prevalence of asthma and is associated with worse outcomes. There are unique research and clinical challenges while managing this group of patients.

Keywords

Obesity Asthma Management Biologics Severe 

Notes

Compliance with Ethical Standard

Conflict of Interest

Njira Lugogo reports grants, personal fees, and non-financial support from GSK; grants and personal fees from AstraZeneca; personal fees from TEVA; grants and personal fees from Genentech; grants and personal fees from SANOFI/Regeneron; and personal fees from Norvartis outside the submitted work. Arjun Mohan, Jon Grace, and Bonnie Wang declare no conflicts of interest relevant to this manuscript.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Arjun Mohan
    • 1
  • Jon Grace
    • 2
  • Bonnie R. Wang
    • 2
  • Njira Lugogo
    • 2
    Email author
  1. 1.Division of Pulmonary and Critical Care MedicineEast Carolina UniversityGreenvilleUSA
  2. 2.Division of Pulmonary and Critical Care MedicineUniversity of MichiganAnn ArborUSA

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