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Bitter Taste Receptors: an Answer to Comprehensive Asthma Control?

  • Ajay P. Nayak
  • Dominic Villalba
  • Deepak A. DeshpandeEmail author
Basic and Applied Science (I Lewkowich, Section Editor)
  • 37 Downloads
Part of the following topical collections:
  1. Topical Collection on Basic and Applied Science

Abstract

Purpose of Review

Asthma is marked by peculiar pathological features involving airway contraction, an impinging inflammation in the lungs, and an inexorably progressive remodeling of pulmonary architecture. Current medications for management of asthma exacerbations fail to optimally mitigate these pathologies, which is partly due to the intrinsic heterogeneity in the development and progression of asthma within different populations. In recent years, the discovery of the ectopic expression of TAS2Rs in extraoral tissues and different cell types, combined with significant strides in gaining mechanistic understanding into receptor signaling and function, has revealed the potential to target TAS2Rs for asthma relief.

Recent Findings

TAS2R activation leads to relaxation of airway smooth muscle cells and bronchodilation. In addition, findings from preclinical studies in murine model of asthma suggest that TAS2R agonists inhibit allergen-induced airway inflammation, remodeling, and hyperresponsiveness.

Summary

In this review, we expand on the opportunity presented by TAS2Rs in the development of a comprehensive asthma treatment that overcomes the limitations set forth by current asthma therapeutics.

Keywords

Asthma TAS2R Bitter tastant Airway smooth muscle SCC 

Notes

Funding Information

This study was supported by grants from American Asthma Foundation, and National Heart, Lung, Blood Institute Grant R01HL137030.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: •• Of major importance

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Ajay P. Nayak
    • 1
  • Dominic Villalba
    • 1
  • Deepak A. Deshpande
    • 1
    Email author
  1. 1.Department of Medicine, Center for Translational Medicine and Division of Pulmonary, Allergy and Critical Care Medicine; and Jane & Leonard Korman Respiratory InstituteThomas Jefferson UniversityPhiladelphiaUSA

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