IgE Test in Secretions of Patients with Respiratory Allergy
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Purpose of Review
IgE is a key player in multiple inflammatory airway diseases. Ample literature demonstrates its presence in mucosa of patients with allergic rhinitis (AR), local allergic rhinitis (LAR), asthma, or chronic rhinosinusitis with nasal polyposis (CRSwNP).
Current evidence shows that high-affinity IgE in blood stream of allergic individuals derives mainly from the mucosae. Also, mucosal synthesis of IgE can occur in the absence of systemic atopy, and may be relevant in atopic and non-atopic phenotypes of rhinitis as demonstrated in LAR. Specific IgE (sIgE) detection varies depending on technique used for sample collection and its measurement. sIgE detection is highly specific for diagnosis of LAR. Moreover, measurement of sIgE in secretions could be useful in monitoring response to allergen-specific immunotherapy in both AR and LAR phenotypes.
This review will focus on recent developments in the role of IgE in respiratory diseases, and the clinical implications of its measurement in secretions.
KeywordsAllergic IgE Local allergic rhinitis Rhinitis Allergen-specific immunotherapy
The authors’ research is supported by the Institute of Health “Carlos III” of the Ministry of Economy and Competitiveness (grants cofounded by European Regional Development Fund (ERDF)): ARADyAL RD16/0006/0001, FIS PI12/00900, FIS PI14/00864, and FIS PI17/01410; Andalusian Regional Ministry Health grants PI-0346-2016 and PC-0098-2017; and Institute of Health “Carlos III” through its “Rio Hortega” funding scheme (CM17/00140). Dr. Shamji reports grants from Immune Tolerance Network, NIAID, Regeneron, USA, and grants from Biotech Tools, outside the submitted work.
Compliance with Ethical Standards
Conflict of Interest
The authors declare no conflicts of interest relevant to this manuscript.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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