Biomarkers in Food Allergy

  • Antonella MuraroEmail author
  • Stefania Arasi
Food Allergy (T Green, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Food Allergy


Purpose of Review

To familiarize the reader with the concept of precision medicine in food allergy by dealing with the current biomarkers for the diagnosis, prognosis, and management of the disease.

Recent Findings

Many efforts have been devoted in order to characterize reliable biomarkers able to identify specific phenotypes and endotypes in food allergy. Specific IgE (sIgE), sIgE/total IgE ratios, and T cell assays are just a few candidates that have been investigated over time. With the advent of omics sciences, a new era is commencing. A better understanding of pathogenesis of food allergy and mechanisms of action of the different therapeutic options will allow the accurate selection of the appropriate patient.


In the near future, advances in technologies and data interpretation will allow a better understanding of the pathogenesis of food allergy and the identification of proper biomarkers for a personalized treatment tailored on the specific patient’s profile.


Biomarkers Diagnosis Food allergy Omics Precision medicine Prediction 



basophil activation test


cow’s milk


IgE-mediated food allergy


forced expiratory volume in one second/forced vital capacity


hen’s egg


intestinal epithelial cell


likelihood ratio


lipid transfer proteins


mast cell activation test


molecular diagnostics


mass spectrometry


negative predictive value


oral food challenge


oral immunotherapy


peanut allergy


pathogenesis-related protein-10


positive predictive value


specific immunoglobulin E


skin prick test


regulatory T cell


Compliance with Ethical Standards

Conflict of Interest

The authors declare no conflicts of interest relevant to this manuscript.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Woman and Child Health, Referral Centre for Food Allergy Diagnosis and Treatment Veneto RegionUniversity of PaduaPaduaItaly
  2. 2.Allergy UnitBambino Gesù Children’s HospitalRomeItaly

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