Biomarkers in Food Allergy
Purpose of Review
To familiarize the reader with the concept of precision medicine in food allergy by dealing with the current biomarkers for the diagnosis, prognosis, and management of the disease.
Many efforts have been devoted in order to characterize reliable biomarkers able to identify specific phenotypes and endotypes in food allergy. Specific IgE (sIgE), sIgE/total IgE ratios, and T cell assays are just a few candidates that have been investigated over time. With the advent of omics sciences, a new era is commencing. A better understanding of pathogenesis of food allergy and mechanisms of action of the different therapeutic options will allow the accurate selection of the appropriate patient.
In the near future, advances in technologies and data interpretation will allow a better understanding of the pathogenesis of food allergy and the identification of proper biomarkers for a personalized treatment tailored on the specific patient’s profile.
KeywordsBiomarkers Diagnosis Food allergy Omics Precision medicine Prediction
basophil activation test
IgE-mediated food allergy
forced expiratory volume in one second/forced vital capacity
intestinal epithelial cell
lipid transfer proteins
mast cell activation test
negative predictive value
oral food challenge
positive predictive value
specific immunoglobulin E
skin prick test
regulatory T cell
Compliance with Ethical Standards
Conflict of Interest
The authors declare no conflicts of interest relevant to this manuscript.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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