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Biomarkers in Food Allergy

  • Antonella Muraro
  • Stefania Arasi
Food Allergy (T Green, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Food Allergy

Abstract

Purpose of Review

To familiarize the reader with the concept of precision medicine in food allergy by dealing with the current biomarkers for the diagnosis, prognosis, and management of the disease.

Recent Findings

Many efforts have been devoted in order to characterize reliable biomarkers able to identify specific phenotypes and endotypes in food allergy. Specific IgE (sIgE), sIgE/total IgE ratios, and T cell assays are just a few candidates that have been investigated over time. With the advent of omics sciences, a new era is commencing. A better understanding of pathogenesis of food allergy and mechanisms of action of the different therapeutic options will allow the accurate selection of the appropriate patient.

Summary

In the near future, advances in technologies and data interpretation will allow a better understanding of the pathogenesis of food allergy and the identification of proper biomarkers for a personalized treatment tailored on the specific patient’s profile.

Keywords

Biomarkers Diagnosis Food allergy Omics Precision medicine Prediction 

Abbreviations

BAT

basophil activation test

CM

cow’s milk

FA

IgE-mediated food allergy

FEV1/FVC

forced expiratory volume in one second/forced vital capacity

HE

hen’s egg

IEC

intestinal epithelial cell

LR

likelihood ratio

LTP

lipid transfer proteins

MAT

mast cell activation test

MD

molecular diagnostics

MS

mass spectrometry

NPV

negative predictive value

OFC

oral food challenge

OIT

oral immunotherapy

PA

peanut allergy

PR-10

pathogenesis-related protein-10

PPV

positive predictive value

sIgE

specific immunoglobulin E

SPT

skin prick test

Treg

regulatory T cell

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare no conflicts of interest relevant to this manuscript.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Woman and Child Health, Referral Centre for Food Allergy Diagnosis and Treatment Veneto RegionUniversity of PaduaPaduaItaly
  2. 2.Allergy UnitBambino Gesù Children’s HospitalRomeItaly

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