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Clinical experience with trans-catheter aortic valve implantation at a tertiary hospital in the Republic of Ireland

  • Richard TannerEmail author
  • Barbara Moran
  • Ronan Margey
  • Gavin Blake
  • Catherine McGorrian
  • Jacqueline Geraghty
  • Susan Groarke
  • Jana Boleckova
  • John Hurley
  • Andrew Roy
  • David Barton
  • Declan Sugrue
  • Ivan P. Casserly
Original Article
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Abstract

Introduction

There is a paucity of published data on the clinical experience with trans-catheter aortic valve implantation (TAVI) in the Republic of Ireland. We sought to examine the clinical outcomes of patients with medium-term follow-up treated with TAVI at our institution.

Methods

A prospective TAVI registry was used to assess the baseline demographics, procedural variables and clinical outcomes of patients treated with TAVI between the inception of the programme in 2008 and November 2017.

Results

A total of 354 patients (mean age 80.9 ± 8.1 years, 58% male, mean STS score 6.1 ± 4.3%) were treated during the study period. Major in-hospital outcomes included in-lab death (n = 2, 0.6%), stroke (n = 8, 2.2%), device embolisation (n = 4, 1.2%), permanent pacemaker implantation (n = 22, 6.2%) and major vascular complication (n = 2, 0.6%). The median length of hospital stay was 4 days (IQR 2–8 days). The Kaplan-Meier estimate of freedom from death at 30 days and 1 year for the entire cohort was 97 ± 1% and 85.4 ± 2.3%, respectively. Trans-femoral access was associated with a significantly lower rate of death and/or stroke at 1 year compared to trans-apical access (84.9 ± 2.4% versus 60 ± 8.9%, p = 0.0005). There was no significant difference in freedom from death and/or stroke at 1 year between balloon-expandable and self-expanding valves (81.6 ± 2.6% versus 84.4 ± 7.4%, p = 0.63).

Conclusion

This study documents low complication rates and favourable rates of survival following TAVI in a consecutive series of patients undergoing TAVI at a tertiary referral centre in the Republic of Ireland. These data support the application of this therapy in the Irish context.

Keywords

Aortic stenosis Clinical outcomes Ireland TAVI Trans-catheter aortic valve replacement 

Notes

Compliance with ethical standards

Ethical approval for this study was obtained from the Research Ethics Committee, Mater Misericordiae University Hospital (Ref: 1/378/1882 TMR).

Conflict of interest

Jana Boleckova is an employee of Edwards Lifesciences.

No other conflicts of interest to declare.

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Copyright information

© Royal Academy of Medicine in Ireland 2019

Authors and Affiliations

  • Richard Tanner
    • 1
    Email author
  • Barbara Moran
    • 2
  • Ronan Margey
    • 2
  • Gavin Blake
    • 1
  • Catherine McGorrian
    • 1
  • Jacqueline Geraghty
    • 1
  • Susan Groarke
    • 1
  • Jana Boleckova
    • 3
  • John Hurley
    • 2
  • Andrew Roy
    • 2
  • David Barton
    • 2
  • Declan Sugrue
    • 2
  • Ivan P. Casserly
    • 1
    • 2
  1. 1.Department of CardiologyMater Misericordiae University HospitalDublin 7Ireland
  2. 2.Mater Private HospitalDublin 7Ireland
  3. 3.Edwards Lifesciences AGPragueCzech Republic

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