Irish Journal of Medical Science (1971 -)

, Volume 188, Issue 1, pp 311–319 | Cite as

Evaluation of factors affecting time to achieve dry weight among hemodialysis patients using bioimpedance spectroscopy

  • Amjad KhanEmail author
  • Amer Hayat Khan
  • Azreen Syazril Adnan
  • Syed Azhar Syed Sulaiman
  • Nafees Ahmad
  • Siew Hua Gan
Original Article



Achieving and maintaining dry weight appears to be an effective strategy for controlling and maintaining normotension among hypertensive patients on hemodialysis (HD).


The present study aimed to determine the time at which the majority of patients achieve postdialysis dry weight using bioimpedance spectroscopy (BIS).


A total of 220 HD patients were prospectively assessed for fluid overload using the Fresenius body composition monitor (BCM). BCM readings were taken at 30 and 45 min postdialysis.


Among the 220 patients included in this study, 120 (54.5%) achieved a euvolemic state at 30 min, and 25 (11.4%) achieved it at 45 min according to the BCM. In the multivariate analysis, vascular access other than arteriovenous fistula (AVF) (OR = 0.286, p value = 0.049) and cardiovascular disease (OR = 0.384, p value = 0.026) had a statistically significant negative association and receiving HD at Hospital Universiti Sains Malaysia (HUSM) (OR = 2.705, p value = 0.008) had a statistically significant positive association with achieving a euvolemic state at 30 min.


This suggests that assessing the hydration status at 45 min postdialysis in all patients or in those with identified risk factors for not achieving a euvolemic state at 30 min will provide a relatively accurate assessment for most patients.


Body composition monitor Dry weight Hemodialysis Hypertension 



We are thankful to the Institute of Postgraduate Studies (IPS) of Universiti Sains Malaysia (USM) for the fellowship support (ref. no. P-FD0011/15(R)).

Authors’ contributions

Conceived and designed the experiments: AK and AHK. Performed the experiments: AK, AHK, and ASA. Analyzed the data: AK and NA. Contributed reagents/materials/analysis tools: SASS, AK, and SHG. Wrote the paper: AK. Final approval of manuscript: AHK, ASA, and SASS.

Support/funding information

Authors have no support or funding for current manuscript.

Compliance with ethical standards

Competing interests

The authors declare that they have no competing interests.

Ethics approval

Our study was approved by the Human Resource Ethics Committee of Hospital Universiti Sains Malaysia (USM/JEPeM/16020058). All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Royal Academy of Medicine in Ireland 2018

Authors and Affiliations

  1. 1.Discipline of Clinical Pharmacy, School of Pharmaceutical SciencesUniversiti Sains MalaysiaPenangMalaysia
  2. 2.Chronic Kidney Disease Resource Centre, School of Medical Sciences, Health CampusUniversiti Sains MalaysiaKubang KerainMalaysia
  3. 3.Department of PharmacyQuaid-i-Azam UniversityIslamabadPakistan
  4. 4.Faculty of Pharmacy and Health SciencesUniversity of BalochistanQuettaPakistan
  5. 5.Human Genome Centre, School of Medical Sciences, Health CampusUniversiti Sains MalaysiaKubang KerianMalaysia

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