Prevalence of sarcopenia in patients with geriatric depression diagnosis
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In this study, the aim was to identify the prevalence of sarcopenia among patients with geriatric depression (GD) diagnosis and to collect data to illuminate precautions to reduce disease load.
The study was completed with 116 patients (GD group) aged 65 years or older with possible or definite depression diagnosis according to the Geriatric Depression Scale (GDS) criteria and 301 volunteers aged from 18 to 39 years (control 1) and above 65 years (control 2). Our prospective and cross-sectional study applied the Hamilton Depression Rating Scale (HDRS) to control 1 group and the GDS and Mini Mental Test (MMSE) to control 2 and GD groups. All groups had skeletal muscle mass index (SMMI), muscle strength, and physical performance assessed with sarcopenia diagnosis according to the European Working Group on Sarcopenia in Older People (EWGSOP) diagnostic criteria.
In our study, in parallel with the severity of disease in patients with GD diagnosis, the prevalence of sarcopenia (led by severe sarcopenia) was observed to be high compared to the control group. The prevalence of sarcopenia was 12.7%/24.2% among women and 13.8%/44.0% among men and 13.4%/32.8% in total in the control 2 and GD groups, respectively. There was a significant increase observed in the prevalence of sarcopenia, led by severe sarcopenia with a definite depression diagnosis.
For GD patients, diagnosis of sarcopenia in the early stages and precautions like improving muscle functions with protein support in diet and resistance exercises will make it possible to contribute to improving clinical results of the disease.
Keywords4-m walking test Geriatric depression Hand grip test Sarcopenia Skeletal muscle mass index
All authors contributed to writing the manuscript. All authors read and approved the final manuscript.
Compliance with ethical standards
To complete this study with the aim of determining the prevalence of sarcopenia among GD patients monitored at Ordu University Education and Research Hospital and Ordu State Hospital neurology clinics, permission was obtained from General secretary of Ordu Provincial Union of Public Hospitals and Ordu University Education and Research Hospital ethics committee with 2018/85 decision number. Participation in the research was on a voluntary basis, with no names written on data collection forms. Patients and patient relatives were informed that information collected would not be used apart from the aims of the research. Written informed consent was obtained from all participants included in the study.
Conflict of interest
The authors declare that they have no competing interest.
The authors would like to thank to Dr. Yeliz KAŞKO ARICI (Bioistatistics and Medical Informatics Unit, Faculty of Medicine, Ordu University) for her help with the stastistical analyses of this manuscript.
- 6.Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinkova E, Vandewoude M, Zamboni M (2010) Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing 39(4):412–423CrossRefGoogle Scholar
- 8.Alexandre Tda S, Duarte YA, Santos JL, Wong R, Lebrao ML (2014) Sarcopenia according to the European Working Group on Sarcopenia in Older People (EWGSOP) versus dynapenia as a risk factor for mortality in the elderly. J Nutr Health Aging 18(8):751–756. https://doi.org/10.1007/s12603-014-0450-3 CrossRefGoogle Scholar
- 15.Fukumori N, Yamamoto Y, Takegami M, Yamazaki S, Onishi Y, Sekiguchi M, Otani K, Konno SI, Kikuchi SI, Fukuhara S (2015) Association between hand-grip strength and depressive symptoms: Locomotive Syndrome and Health Outcomes in Aizu Cohort Study (LOHAS). Age Ageing 44(4):592–598CrossRefGoogle Scholar
- 16.Karan A (2006) Exercise and sports in the elderly. Turk J Phys Med Rehab 52(Suppl A):A53–A56Google Scholar
- 18.Güngen C, Ertan T, Eker E et al (2002) Reliability and validity of the standardized Mini Mental State Examination in the diagnosis of mild dementia in Turkish population. Turk Psikiyatri Derg 13(4):273–281Google Scholar
- 20.Akdemir A, Örsel SD, Dağ I, Türkçapar MH, İşcan N, Özbay H (1996) Clinical use and the reliability and validity of the Turkish version of the Hamilton Depression Rating Scale (HDRS). 3P Dergisi 4:251–259Google Scholar
- 22.Ertan T, Eker E, Şar V (1997) Geriatrik Depresyon Ölçeğinin Türk Yaşlı Nüfusunda Geçerlilik Ve Güvenilirliği. Nöropsikiyatri Arşivi 34(1):62–71Google Scholar
- 23.Sağduyu A (1997) Yaşlılar için depresyon ölçeği: Hamilton depresyon ölçeği ile karşılaştırmalı güvenilirlik ve geçerlilik çalışması. Türk Psikiyatri Dergisi 8:3–8Google Scholar
- 26.Hsu YH, Liang CK, Chou MY, Liao MC, Lin YT, Chen LK, Lo YK (2014) Association of cognitive impairment, depressive symptoms and sarcopenia among healthy older men in the veterans retirement community in southern Taiwan: a cross-sectional study. Geriatr Gerontol Int 14(Suppl 1):102–108CrossRefGoogle Scholar
- 29.Bahat G, Tufan A, Tufan F, Kılıc C, Akpinar S, Kose M (2016) Cut-off points to identify sarcopenia according to European Working Group on Sarcopenia in Older People (EWGSOP) definition. Clin Nutr 2(6):35Google Scholar
- 32.Rodriguez-Rejon AI, Artacho R, Puerta A, Zuñiga A, Ruiz-Lopez MD (2018) Diagnosis of sarcopenia in long-term care homes for the elderly: the sensitivity and specificity of two simplified algorithms with respect to the EWGSOP Consensus. J Nutr Health Aging 22:796–801. https://doi.org/10.1007/s12603-018-1004-x CrossRefGoogle Scholar
- 37.Cruz-Jentoft AJ, Landi F, Schneider SM, Zuniga C, Arai H, Boirie Y, Chen LK, Fielding RA, Martin FC, Michel JP, Sieber C, Stout JR, Studenski SA, Vellas B, Woo J, Zamboni M, Cederholm T (2014) Prevalance of and interventions for sarcopenia in ageing adults: a systematic review. (EWGSOP and IWGS). Age Ageing 43(6):748–759CrossRefGoogle Scholar