Investigating Mg Biocorrosion In Vitro: Lessons Learned and Recommendations
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Magnesium (Mg) alloys are achieving good clinical success in applications as temporary biodegradable medical implants. However, the study of the corrosion in medical environments (biocorrosion) is still ongoing. Much of this study is conducted via laboratory (i.e., in vitro) immersion tests, which can be challenging. We have outlined and updated a range of recommendations on the in vitro biocorrosion assessment of Mg alloys, based on our experience in the field and the lessons learned through years of experiments. We hope these recommendations will help to improve future biocorrosion testing and provide insight for both researchers with experience in this field and those seeking to enter it.
This work was supported by the Australian Federal Government through an Australian Government Research Training Program Scholarship. The authors acknowledge the Australian Research Council (ARC) (Grant Nos. LP150100950, IH150100024, and DP170102557). M.S.D. and S.J. acknowledge the support of the ARC Research Hub for Advanced Manufacturing of Medical Devices. The staff of the University of Queensland Biological Resourced (UQBR) Department, in particular Mrs. Kym French, are also gratefully acknowledged for their assistance and expertise in animal handling and care. The National Imaging Facility at the Centre for Advanced Imaging (CAI) is acknowledged for their assistance and expertise with the imaging conducted in this study.
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