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JOM

, Volume 71, Issue 1, pp 294–301 | Cite as

Cytotoxicity of Bacteriostatic Reduced Graphene Oxide-Based Copper Oxide Nanocomposites

  • Xiangyang Xu
  • Jing Shen
  • Jingyu Qin
  • Huimin Duan
  • Guangyu He
  • Haiqun ChenEmail author
Materials in Nanomedicine and Bioengineering
  • 43 Downloads

Abstract

An antibacterial nanocomposite, reduced graphene oxide-based copper oxide (CuO-RGO), was prepared by a one-step hydrothermal method and characterized by x-ray diffraction analysis, infrared absorption spectroscopy, scanning electron microscopy, transmission electron microscopy, and photoluminescence measurements, revealing CuO nanoparticles with diameter of about 26 nm uniformly anchored on graphene sheets. Compared with recently reported bacteriostatic agents, much less CuO-RGO is required and better bacteriostatic effect is achieved, with good stability. The minimum inhibitory concentration of the CuO-RGO composite against Escherichia coli reached 240 μg mL−1. The antibacterial rate remained at 89% after five cycles. In addition, introduction of graphene inhibited leaching of Cu2+, which reduces the cytotoxicity of CuO-RGO to mouse fibroblast L929.

Notes

Acknowledgements

The authors are grateful for financial support from the National Nature Science Foundation of China (Nos. 51572036, 51472035), Science and Technology Department of Jiangsu Province (BY2015027-18, BY2016029-12), Changzhou Key Laboratory of Graphene-Based Materials for Environment and Safety (CE20160001-2, CM20153006), and PAPD of Jiangsu Higher Education Institution.

Conflict of interest

The authors declare that they have no conflicts of interest.

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Copyright information

© The Minerals, Metals & Materials Society 2018

Authors and Affiliations

  1. 1.Key Laboratory of Advanced Catalytic Materials and Technology, Advanced Catalysis and Green Manufacturing Collaborative Innovation CenterChangzhou UniversityChangzhouChina

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