pp 1–7 | Cite as

Is there a causal relationship between obstructive sleep apnea and the pathophysiology of intracranial aneurysm?

  • Sebastian ZarembaEmail author
  • Erdem Güresir


Rupture of an intracranial aneurysm (IA) leads to a rare subtype of intracranial bleeding, i. e., subarachnoid hemorrhage (SAH). However, SAH is associated with high long-term morbidity and mortality. Risk factors for the development and rupture of IA include modifiable factors, i. e., smoking and arterial hypertension. Symptoms of obstructive sleep apnea (OSA) are commonly reported following the rupture of an IA. The purpose of this review is to summarize the currently available evidence on the prevalence and effect of OSA in patients with IA. With an exploratory intent, we further identified potential mechanisms by which OSA might promote the development, growth, and rupture of IA.


Subarachnoid hemorrhage Quality of life Intracranial aneurysm Sleep disorders Aneurysm, ruptured 

Besteht ein kausaler Zusammenhang zwischen obstruktiver Schlafapnoe und der Pathophysiologie intrakanieller Aneurysmen?


Die Ruptur eines intrakraniellen Aneurysmas (IA) kann zu einem seltenen Subtyp einer intrakraniellen Blutung, d. h. zu einer Subarachnoidalblutung (SAB), führen. Dabei geht eine SAB mit einer hohen Langzeitmorbidität und -mortalität einher. Zu den Risikofaktoren für die Entstehung und Ruptur eines IA gehören modifizierbare Faktoren wie Rauchen und arterielle Hypertonie. Häufig wird nach der Ruptur eines IA über Symptome einer obstruktiven Schlafapnoe (OSA) berichtet. Ziel der vorliegenden Übersichtsarbeit ist es, eine Zusammenfassung der derzeit verfügbaren Evidenz zur Prävalenz und zu den Auswirkungen einer OSA bei Patienten mit IA zu geben. Um dies näher zu untersuchen, ermittelten die Autoren potenzielle Mechanismen, durch welche eine OSA die Entstehung, das Wachstum und die Ruptur eines IA begünstigen könnte.


Subarachnoidalblutung Lebensqualität Intrakranielles Aneurysma Schlafstörungen Aneurysma, rupturiertes 


Compliance with ethical guidelines

Conflict of interest

S. Zaremba and E. Güresir declare that they have no competing interests.

This article does not contain any studies with human participants or animals performed by any of the authors.


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© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2019

Authors and Affiliations

  1. 1.Department of NeurologyRheinische Friedrich-Wilhelms-UniversityBonnGermany
  2. 2.Department of NeurosurgeryRheinische Friedrich-Wilhelms-UniversityBonnGermany

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