Optoelectronics Letters

, Volume 14, Issue 5, pp 346–349 | Cite as

Thin-core fiber-optic biosensor for DNA hybridization detection

  • Shao-Cong Long (龙少聪)
  • Yan-Ru Zhu (朱彦儒)
  • Mu-Yun Hu (胡慕芸)
  • Yi-Fan Qi (祁一凡)
  • Yun-Rui Jiang (蒋韵睿)
  • Bo Liu (刘波)Email author
  • Xu Zhang (张旭)


A real-time label-free DNA biosensor based on thin-core fiber (TCF) interferometer is demonstrated experimentally. The proposed biosensor is constructed by splicing a TCF between two segments of single mode fibers (SMFs) and integrated into a microfluidic channel. By modifying the TCF surface with monolayer poly-l-lysine (PLL) and single-stranded deoxyribonucleic acid (ssDNA) probes, the target DNA molecules can be captured in the microfluidic channel. The transmission spectra of the biosensor are measured and theoretically analyzed under different biosensing reaction processes. The results show that the wavelength has a blue-shift with the process of the DNA hybridization. Due to the advantages of low cost, simple operation as well as good detection effect on DNA molecules hybridization, the proposed biosensor has great application prospects in the fields of gene sequencing, medical diagnosis, cancer detection and environmental engineering.

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Copyright information

© Tianjin University of Technology and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Shao-Cong Long (龙少聪)
    • 1
  • Yan-Ru Zhu (朱彦儒)
    • 1
  • Mu-Yun Hu (胡慕芸)
    • 1
  • Yi-Fan Qi (祁一凡)
    • 1
  • Yun-Rui Jiang (蒋韵睿)
    • 1
  • Bo Liu (刘波)
    • 1
    Email author
  • Xu Zhang (张旭)
    • 1
  1. 1.Tianjin Key Laboratory of Optoelectronic Sensor and Sensing Network Technology, Institute of Modern OpticsNankai UniversityTianjinChina

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